FDA: Approve High Dose IV Vitamin C for Coronavirus Patients!

FDA: Approve High Dose IV Vitamin C for Coronavirus Patients!

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The Coronavirus IVC Project started this petition to President Donald J. Trump and

Brief Summary

There have been emerging reports favoring Vitamin C administered intravenously (IV) alone or in in combination with hydroxychloroquine/chloroquine as a very effective treatment for Coronavirus COVID-19 patients in China and U.S. Unfortunately, IV Vitamin C's has not yet been recognized or explored by the FDA, CDC, or HHS.

As of March 2020, only hydroxychloroquine, chloroquine, and remdisivir are listed as potential therapeutics for COVID on the CDC website. They are FDA approved for "emergency use," meaning that doctors can prescribe them for Coronavirus even though formal clinical trials have not been completed. *As of January 2021, chloroquine and hydroxychloroquine have been revoked.

Based upon several recent case studies of IV Vitamin C and its beneficial effects for Coronavirus patients, we are petitioning the President, FDA, politicians, and other health officials to immediately grant High Dose IV Vitamin C emergency use authorization for Covid-19 treatment 

Dr. Richard Cheng

U.S. board certified anti-aging physician, Dr. Richard Cheng, MD,Ph.D serves on the Medical and Scientific Advisory Board to the International Intravenous Vitamin C China Epidemic Medical Support Team. He has been a pioneer in facilitating these new COVID IVC research studies abroad. Dr. Cheng published a review article for Elsevier Medicine in Drug Discovery Journal on I.V. Vitamin C for Coronavirus:

"High-dose intravenous VC has also been successfully used in the treatment of 50 moderate to severe COVID-19 patients in China. The doses used varied between 2 g and 10 g per day, given over a period of 8–10 h. Additional VC bolus may be required among patients in critical conditions. The oxygenation index was improving in real time and all the patients eventually cured and were discharged. In fact, high-dose VC has been clinically used for several decades and a recent NIH expert panel document states clearly that this regimen (1.5 g/kg body weight) is safe and without major adverse events" (Cheng).


3 Further Reasons to Combine IVC with or without Hydroxychloroquine/Remdesivir/Azithromycin During Coronavirus Treatment

1. Reported success by a New York Physician

2. Reported success at the Xi’an Jiaotong University Second Hospital

3. Endorsed by the Shanghai Medical Association

4. Several case studies of COVID patients experiencing severe symptoms fully recovering after given IVC. 

5. Dr. Marik MATH+ Protocol for COVID includes high dose IVC for ICU admitted patients.

The Shanghai Medical Association (SMA), established in 1917, had recently published their official consensus on Coronavirus treatment based upon several clinical trials involving about 300 patients in China. They advise doctors use IV Vitamin C in combination with hydroxychlorquine and/or chloroquine antivirals.

For patients experiencing mild symptoms, they recommend 50-100 mg/kg of body weight per day of high dose IV Vitamin C (IVC) (Taylor). This is equivalent to about 2,500-4,700 mg IVC for a 110 lb individual or 4,000 - 9,000 mg IVC per day for a 200 lb individual.

For severe and critically ill patients, the SMA recommend 100 - 200 mg/kg IVC. This is equivalent to about 4,700 - 9,000 mg IVC for a 110 lb individual or 9,000 - 18,000 mg IVC per day for a 200 lb individual. 

The full, comprehensive report can be accessed here, however, you may need to use Google translate.


The National Institute of Health (NIH) website refers to a study where IV Vitamin C (IVC) was safely tolerated up to 1.5 grams/kg body weight per day for healthy individuals and cancer patients without existing kidney disease, kidney stones, or G6PD deficiency (NIH). This translates to about 75 grams/day IVC for a 110 lb individual and 150 grams/day IVC for a 200 lb individual! The Chinese observed benefits at much smaller doses relative to these doses. We do not predict that such doses would be required for treating COVID.

There are additional clinical trials in China underway studying the effects of high dose IV Vitamin C for Coronavirus patients at dosages of 12-24 grams/day and another study at 6-12 grams/day (Saul). The U.S., however, has not really completed any research or inquiry into Coronavirus IVC whatsoever.

The Xi’an Jiaotong University Second Hospital also endorsed IV Vitamin C therapy claiming "that for patients with severe neonatal pneumonia and critically ill patients, vitamin C treatment should be initiated as soon as possible after admission" (World Health). Eight of their patients with Coronavirus acquired pneumonia recovered following IV Vitamin C treatment, respectively.

IVC Introduced at 23 NY Hospitals

IV Vitamin C has recently had a small, but growing presence in the U.S. Dr. Andrew Weber, a New York pulmonologist, has already gave some of his Coronavirus patients 1.5 grams IV Vitamin C 3x day with good results. Weber claimed "that patients who received Vitamin C did significantly better than those who did not get Vitamin C" (Mongelli et. al). Weber, along with other doctors throughout the 23-hospital Northwell Hospital Network, have been integrating IV Vitamin C in their treatments for Coronavirus patients. A representative from Northwell claimed that IVC usage for Coronavirus is "widespread" throughout their system. These New York doctors are not using IVC alone, but in combination with hydroxychloroquine and/or azithromycin. So why aren't other hospitals using it? Simply because they are unaware of it. With FDA recognition and approval, more doctors and hospitals would become aware.

IVC and Sepsis

Sepsis, is a life threatening condition where the body produces chemicals that can result in tissue damage, organ failure, and mortality. Usually, a pre existing bacterial infection such as a urinary tract infection or pneumonia leads to an increased presence and multiplication of bacteria in the bloodstream, or septicemia. Symptoms include: fever, increased heart rate, shortness of breath, sweating, and confusion.

The mortality rate is usually 30%-35% in the U.S. and even greater in 3rd world countries.

Fortunately, IV Vitamin C, when administered with Vitamin B1 and corticosteroids by Virginia physician, Dr. Paul Marik, was shown to reduce sepsis related deaths by 32% from 19/47 to 4/47 in a small clinical study (Marik et.al). Interestingly, COVID patients have and are continuing to experience sepsis, without IVC intervention. Arguably, IVC has been a clinically proven treatment with regards to sepsis and one could only wonder its potential for Coronavirus.

The Marik Vitamin C Protocol:

  1. 1.5 grams IVC every 6 hours x4 days or sooner if discharged
  2. 50 mg IV hydrocortisone every 6 hours x7 days
  3. 200 mg IV Thiamine (B1) every 12 hours x4 days

In this protocol, a patient could theoretically receive up to 6 grams IVC in a day.

The world-renowned, Cleveland Clinic, also studied IV Vitamin C for sepsis patients and also concluded that it significantly increased survival rate and reduced length of ICU stay (Cleveland).  We have confidence that IV Vitamin C will also have great results for Coronavirus patients.


The Marik Study of 94 patients

47/94 Sepsis/Septic Shock patients received 6 grams IVC per day along with IV hydrocortisone and IV Thiamine

47/94 Sepsis/Septic Shock received the placebo

IVC Group Mortality rate: 8%

The other group: 40%

This is a 32% decrease in mortality rate!

Marik P.E., Khangoora V., Rivera R., Hooper M.H., Catravas J. Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study. Chest. 2017;151:1229–1238. doi: 10.1016/j.chest.2016.11.036.


A group of 14 septic shock patients that received 25 mg/kg IVC every 6 hours for 3 days had a mortality rate of 14% compared to 64% in the other group of 14 septic shock patients that received no treatment.

Zabet M.H., Mohammadi M., Ramezani M., Khalili H. Effect of high-dose Ascorbic acid on vasopressor’s requirement in septic shock. J. Res. Pharm. Pract. 2016;5:94–100


Cleveland Clinic CITRIS ALI Trial

30% mortality in IVC group vs 46% mortality rate in the other group

Fowler A.A., Truwit J.D., Hite R.D., Morris P.E., DeWilde C., Priday A., Fisher B., Thacker L.R., Natarajan R., Brophy D.F., et al. Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial. JAMA. 2019;322:1261–1270. doi: 10.1001/jama.2019.11825

Would the benefits experienced in 2017 apply again in 2020 Coronavirus? 

Very likely. Sepsis in 2017 is Sepsis in 2020. ARDS in 2017 is ARDS in 2020. I would assume that  sepsis or ARDS has not changed itself with the 3 years. 

So lets pretend that diabetes (high blood sugar) was a complication of Coronavirus. Diabetics usually take metformin to reduce their sugar levels in real life. Would it be rational to give Coronavirus Diabetics metformin? Absolutely. But by the FDA standards, they would probably argue that metformin has to be proven to work in Coronavirus patients before approval.

The Physician's Weekly recently suggested exploring high dose IV Vitamin C to Coronavirus patients experiencing ARDS, acute respiratory distress syndrome, may be a good idea.

"Treatment of severe ARDS from COVID-19 is an ongoing challenge and a specific treatment could be months ahead. The evidence around vitamin C is scarce but promising. There probably never was and never will be a better time than the current to explore and make use of every possible tool that could allow us to improve patients’ prognosis and expand the body of evidence for the benefit of all" (High Dose). 

IVC and ARDS Research


16 ARDS patients were given 1 gram IVC every 6 hours along with selenium, NAC, and Vitamin E.

Another 16 ARDS patients received placebo or sugar water

The mortality rate in the IVC group was 37% compared to 71% in the other group. 

That's a nearly 40% decrease in mortality rate!

Sawyer M.A.J., Mike J.J., Chavin K., Marino P.L. Antioxidant therapy and survival in ARDS. Crit. Care Med. 1989;17:S153.

Coincidentally, Sepsis and ARDS are common complications seen in hospitalized Coronavirus patients. When these research studies were being done, Coronavirus did not cause the Sepsis or ARDS. But it would be fair to assume that it would still work for Sepsis and ARDS that is caused by the Coronavirus.

According to the CDC, 67-75% of ICU admitted Coronavirus patients, develop ARDS!


So each disease has symptoms and complications. Just because something is not proven to treat the symptoms, does not mean it cannot treat the complications. COVID complications are ARDS, sepsis, and septic shock. These complications can be caused by other diseases also. So IVC has already significant research that it can work for treating the complications. There should be no requirement to create a new research study to test the effect of vitamin c for COVID caused ARDS/Sepsis when there was already research done for vitamin c for Non-COVID caused ARDS/Sepsis. 

Further, we request observational research studies be conducted for IVC Coronavirus patients. An observational study means that everyone being studied will be given the potential treatment/medication. This is easier and cheaper to perform and confers benefits to every patient. Case studies can then be compiled and published online.

Interestingly, some U.S. oncologists offer IVC in conjunction with chemotherapy to improve results. We do not see why IVC cannot serve a similar purpose with respect to COVID and its proposed pharmaceuticals. 

Current F.D.A. Vitamin C Recommended Daily Allowance

Women: 75 mg/day

Men: 90 mg/day

Tolerable Upper Limit: 2000 mg/day

We believe that these doses may be appropriate for a healthy individual and encourage people to adhere to these FDA recommendations. Interestingly, these guidelines were originally created to prevent Scurvy and not designed for optimal health performance or treating other diseases such as COVID.

Nevertheless, we still advise against self administering high dose Vitamin C greater than 2 grams/day without the supervision of a licensed medical doctor.  

It should further be noted that individuals with existing renal disease, Glucose-6-Phosphate Dehydrogenase Deficiency (G6PD), kidney stones, or Hemochromatosis should avoid high dose Vitamin C. 

IV Vitamin C Facts

1. Clinically proven to reduce sepsis related deaths

2. Used by some U.S. oncologists when treating cancer patients to reduce side effects and improve quality of life

3. Potency. Per NIH, "When taken by IV infusion, vitamin C can reach higher levels in the blood than when the same amount is taken by mouth" (NIH)

4. Well tolerated. Excess amount would safely be excreted in the urine as it is a water-soluble vitamin. Studies suggest up to 1.5 g/kg can safely be tolerated if one does not have kidney stones, kidney disease, G6PD deficiency, or Hemochromatosis.

5. It is relatively inexpensive to produce.

6. Hospitals usually have a good supply of it and if not, can readily order it from a U.S. based supplier. 

Admittedly, We acknowledge that the success experienced with IVC for Coronavirus thus far are case studies and anecdotal in nature. They may or may not work in a larger research study, but its our belief that further exploration is well warranted! Hydroxychloroquine, although originally approved for malaria, only has anecdotal evidence for Coronavirus. As of March 2020, it is FDA approved for compassionate use while official studies are still in progress.  Thus, we would appreciate it if you could please fairly evaluate IV Vitamin C in a similar manner. We hypothesize that vitamin C would improve survival rates, quality of life, and reduce length of ICU duration stay. We encourage you to do your own due diligence and if you agree with this petition, please sign!

We, the signed, request that you explore IV Vitamin C as another Coronavirus treatment option and immediately include it your online list of existing Coronavirus therapeutics for doctor usage by granting it "compassionate use" approval. Subsequently, we request further U.S. based research studies on its use. We do not claim IVC is a COVID cure, but rather, a potential, experimental treatment that requires further evaluation. What if we are challenged with another highly aggressive virus, bacteria, etc and cannot afford to wait while we "develop" a new medicine or vaccine? We should have a dependable, inexpensive, easily manufactured, universal therapeutic that can be given while the biotech, pharmaceutical industries work on researching and developing their own stuff. 

Thank you for your time and consideration.



The Coronavirus IVC Project



**Update**In the few weeks since this petition was created, various IVC Coronavirus clinical trials are now active, but still worth knowing that the studies may require months or years before actually being completed.

The FDA after receiving the materials declined approval without solid clinical trial evidence. They indicated that clinical trials must be done to prove whether it works.  The CDC and HHS indicated they cannot do anything regarding this. 

Hunter Holmes McGuire Veteran Affairs Medical Center https://clinicaltrials.gov/ct2/show/NCT04357782?cond=Coronavirus+Vitamin+C&draw=2&rank=1

The Cleveland Clinic is also giving 8,000 mg daily Vitamin C tablets to Coronavirus patients to see if it can prevent disease progression. Although this is not intravenous Vitamin C, it is still 800x the FDA recommended daily allowance of 90 mg.


Virginia Commonwealth University plans on giving IVC to ICU admitted Coronavirus patients


Canadian University of Sherbrook giving IVC to ICU admitted Coronavirus patients




High-Dose IV Vitamin C on ARDS by COVID-19: A Possible Low-Cost Ally With a Wide Margin of Safety April 29 2020https://www.physiciansweekly.com/high-dose-iv-vitamin-c-on-ards-by-covid-19-a-possible-low-cost-ally-with-a-wide-margin-of-safety/

NIH National Cancer Institute. High-Dose Vitamin C (PDQ®)–Health Professional Version. February 2020 https://www.cancer.gov/about-cancer/treatment/cam/hp/vitamin-c-pdq#_18

Cheng Z., Richard. Can early and high intravenous dose of vitamin C prevent and treat coronavirus disease 2019 (COVID-19)?, Medicine in Drug Discovery, 2020,
100028, ISSN 2590-0986 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167497/

Saul, Andrew. China Treating Coronavirus COVID-19 with Intravenous Vitamin C. March 2020. Global Research https://www.globalresearch.ca/three-intravenous-vitamin-c-research-studies-approved-treating-covid-19/5705405

Mongelli, Lorena. Golding, Bruce.  New York hospitals treating coronavirus patients with vitamin C. 24 March 2020. New York Post https://nypost.com/2020/03/24/new-york-hospitals-treating-coronavirus-patients-with-vitamin-c/

Cleveland Clinic. Study Suggests Benefits of Vitamin C for Severe Sepsis. January 2020 https://consultqd.clevelandclinic.org/study-suggests-benefits-of-vitamin-c-for-severe-sepsis/

Chicago Tribune. Under fire, drugmaker to drop claim for special status for promising coronavirus drug, remdesivir. March 2020 https://www.chicagotribune.com/coronavirus/ct-nw--20200325-zo26i3zhxjdk5ikbs3ypch7swq-story.html

Vaccine Impact. More Vitamin C Studies Approved in China to Fight Coronavirus: Therapy Censored in U.S. March 2020 https://vaccineimpact.com/2020/more-vitamin-c-studies-approved-in-china-to-fight-coronavirus-therapy-censored-in-u-s/

Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock. Marik, Paul E. et al. CHEST, Volume 151, Issue 6, 1229 - 1238 https://journal.chestnet.org/article/S0012-3692(16)62564-3/fulltext

Khan HMW, Parikh N, Megala SM, Predeteanu GS. Unusual early recovery of a critical COVID-19 patient after administration of intravenous vitamin C [published online July 14, 2020]. Am J Case Rep. 2020. doi: 10.12659/AJCR.925521.

CDC. Information for Clinicians on Therapeutic Options for COVID-19 Patients. https://www.cdc.gov/coronavirus/2019-ncov/hcp/therapeutic-options.html

CDC. Interim Clinical Guidance for Management of Patients with Confirmed Coronavirus Disease (COVID-19) https://www.cdc.gov/coronavirus/2019-ncov/hcp/clinical-guidance-management-patients.html

Taylor, Paul. Chinese Medical Team Report Successful Treatment Of Coronavirus Patients With High-Dose Vitamin C. March 2020. Dr Rath Health Foundation https://www.dr-rath-foundation.org/2020/03/chinese-medical-team-report-successful-treatment-of-coronavirus-patients-with-high-dose-vitamin-c/

Official Statement From China For Recommended Treatment of COVID-19. March 2020. World Health https://www.worldhealth.net/news/official-statement-china-recommended-treatment-covid-19/



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