A sequel is already in talks for the live action reboot of Lilo & Stitch, with stuff done differently which includes how since Gantu is not in the film, they made Jumba the main villain instead with how things went with him compared to the original film, even as far as showing what he'd have done had he successfully captured Stitch in the original film after the battle that destroys the Pelekai family's home. As far how this sequel should turn out, of course it should use aspects from what came after the 2002 film, including the other 625 experiments, although they this time might not be scattered around Hawaii as doubtfully the live action reboot would be given it's own TV spinoff. I don't think every single other experiment will be featured either, but with whichever experiments do get featured in live action form, they should all be exactly the same with their name and function that they had in fully animated form with Lilo & Stitch: The Series and the east Asian projects, in addition to of course all having the same voice actors who voiced them in Lilo & Stitch: The Series even if who voiced them were straight up voice actors, much like how Chris Sanders continued to voice Stitch.

As for how the sequel to the live action reboot of Lilo & Stitch turns out, it should feature Jumba's old partner Dr. Hamsterviel, who this time around is still on Jumba's side since too is a villain in live action form, in addition to for the first time being voiced by a celebrity and like Jumba being without his accent that he has in fully animated form. And as for how things turn out with the experiments that are featured, they could be used just to get revenge on Lilo and Stitch following the events of the previous film, to which point they might not be able to be considered as cousins and given a true place to belong at with their uses put to good use, although they might actually be able to redeem themselves at the end of the film. One thing's for certain though is that with any live action reboot to a Disney Animated Feature Film, it doesn't hurt to use characters created by DisneyToon Studios and Disney TV Animation in the sequels and tv spinoffs that Walt Disney Animation Studios films were able to have.