Who’s Global Action Plan on Antimicrobial Resistance http://www.who.int/drugresistance/global_action_plan/en/ Dr Margaret Chan is the Director-General of WHO http://www.who.int/dg/en/ The following petition update includes 13 letters sent to the World Health Organization’s Executive Director of the Director-General's Office describing the mishandling of Lyme disease here in the United States and the refusal to recognize persistent Lyme infection. We are three decades into this 21st Century plague with absolutely no end in sight as this global health threat has been horribly mismanaged from the start. Consider writing your own letter of concern to: Dr Ian Smith Executive Director, Office of the Director-General, World Health Organization Office: + 41.22.791.25.36 Mobile: +41.79.249.35.21 Email: smithi@who.int Carbon copy: Sylvie BRIAND briands@who.int Dirk A. ENGELS engelsd@who.int Minghui REN renm@who.int Raymond Bruce J. AYLWARD aylwardb@who.int John Stelling jstelling@whonet.org 1st email to the World Health Organization _____________________________________________________________ From: Carl Tuttle [mailto:runagain@comcast.net] Sent: 15 July 2016 17:38 To: SMITH, Ian Michael Cc: CHAN FUNG, Margaret F.C.; asamoa-baaha@who.int; AYLWARD, Raymond Bruce J.; BUSTREO, Flavia; CHESTNOV, Oleg; FUKUDA, Keiji; INOUE, Hajime; KIENY, Marie-Paule; minghuir@who.int; TROEDSSON, Hans; ramanan@cddep.org Subject: Who’s Global Action Plan on Antimicrobial Resistance Who’s Global Action Plan on Antimicrobial Resistance Dr Margaret Chan Director-General World Health Organization UN High-Level Meeting on antimicrobials—what do we need? Ramanan Laxminarayan ramanan@cddep.org July 15, 2016 World Health Organization Avenue Appia 20 1211 Geneva 27 Switzerland Attn: Ian Smith MD, Executive Director of the Director-General's Office Dear Dr Smith, I am writing to you today because of your background in Tuberculosis. From the WHO website: http://www.who.int/dg/office/smith/en/ “Dr Smith established and managed the Global TB Drug Facility (GDF) in the Stop TB Partnership secretariat. The GDF is an innovative approach launched in early 2001 to secure access to high quality tuberculosis drugs.” On May 23, 2016 researchers from Johns Hopkins published their findings regarding the antimicrobial resistance of Borrelia (The spirochete responsible for Lyme disease) ORIGINAL RESEARCH ARTICLE Front. Microbiol., 23 May 2016 http://dx.doi.org/10.3389/fmicb.2016.00743 1. A Drug Combination Screen Identifies Drugs Active against Amoxicillin-Induced Round Bodies of In Vitro Borrelia burgdorferi Persisters from an FDA Drug Library Jie Feng, Wanliang Shi, Shuo Zhang, David Sullivan, Paul G. Auwaerter and Ying Zhang Excerpt from the Frontiers in Microbiology article: “Under experimental stress conditions such as starvation or antibiotic exposure, Borrelia burgdorferi can develop round body forms, which are a type of persister bacteria that appear resistant in vitro to customary first-line antibiotics for Lyme disease.” 2. Standard antibiotic treatment for Lyme disease does not kill persistent Borrelia bacteria. http://droopyyoupi.blogspot.com/2015/08/standart-antibiotic-treatment-for-lyme.html Quote from Dr. Ying Zhang: -What has tuberculosis and Borrelia burgdorferi in common? In the late stage of the disease occurs persistent (tolerant) bacteria, which essentially means that the bacteria lasts and lasts and lasts. They protect themselves against antibiotics and are difficult to treat. - Both Borrelia burgdorferi and tuberculosis is relatively easy to cure in the early stages, even with the use of one antibiotic. In the late stage it is impossible to cure the disease with the same type of treatment in the acute phase, said Dr. Ying Zhang when he visited the year NorVect conference. -Dr. Ying Zhang is a professor at the Department of Molecular Microbiology and Immunology at the Johns Hopkins Bloomberg School of Public Health. _____________ For the past thirty years, those who have controlled the Lyme disease narrative have been fixated on the acute stage of disease after early treatment. For example: The Centers for Disease Control awarded a 1.5 million dollar grant to New York Medical College where the focus once again was the acute stage of disease. Clin Infect Dis. http://www.ncbi.nlm.nih.gov/pubmed/25888674 Long-term assessment of health-related quality of life in patients with culture-confirmed early Lyme disease. Wormser GP This study excluded the sickest of the patient population focusing on the acute stage of disease after early treatment. The misleading results of Dr Wormser’s study is then assumed to apply to the entire patient population giving the impression that Lyme is a simple nuisance disease (aches and pains of daily living) and patients who are severely disabled are somehow delusional. A complaint was filed with the Office of Research Integrity: Scientific misconduct or criminal offense? https://www.change.org/p/the-us-senate-calling-for-a-congressional-investigation-of-the-cdc-idsa-and-aldf/u/14006106 Wormser’s inaccurate conceptualization of disease has influenced the world’s perceptions and response to Lyme disease. We are dealing with a life-altering/life-threatening infection that belongs in the same health threat category as AIDS, Zika and Ebola but has been misclassified as a simple nuisance disease as reported by the growing worldwide disabled Lyme patient population. Patients who advance to late stage are almost always horribly incapacitated. Lyme is not your average “Nuisance Disease” https://www.change.org/p/the-us-senate-calling-for-a-congressional-investigation-of-the-cdc-idsa-and-aldf/u/11340872 Excerpt: Duke University Professor Neil Spector required a heart transplant after experiencing four years of undiagnosed-untreated Lyme disease. Spector’s book, “Gone in a Heartbeat” discusses the dismissive attitude of physician colleagues and importance of patient self-advocacy. (Many more stories at this link) As identified by Zhang, we are dealing with an antibiotic resistant/tolerant superbug and have been for decades while post-treatment Lyme disease syndrome is simply a fabricated medical condition disguising treatment failure. The focus over three decades has been to discredit the disabled Lyme patient as opposed to finding a cure. The Lyme pandemic is not isolated to one continent as migratory birds are carrying Lyme infected ticks worldwide. First detection of Borrelia burgdorferi sensu lato DNA in king penguins (Aptenodytes patagonicus halli). http://www.ncbi.nlm.nih.gov/pubmed/25150726 Excerpt: Here, the blood of 50 tick-infested adult king penguins (Aptenodytes patagonicus halli) breeding in the Crozet Archipelago (Southern Indian Ocean) was examined for B. burgdorferi sl exposure by serology and for spirochetemia by in vitro DNA amplification. ______________ There is an urgent need to develop an antimicrobial that will successfully eliminate the Lyme disease spirochete along with its persisters. The pain and suffering caused by this infection worldwide is immeasurable. I certainly hope that you take this information seriously as there is no stopping this worldwide health threat. As the world’s leader in international health, it is time for the WHO to recognize that Lyme disease has been horribly mishandled here in the United States and should be aggressively addressed at a level equivalent to other life-altering/life-threatening infections. Respectfully submitted, Carl Tuttle Hudson, NH USA Lyme Disease: Call for a “Manhattan Project” to Combat the Epidemic Raphael B. Stricker and Lorraine Johnson http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879353/ Response from the World Health organization: ________________________________________ From: "Ian Michael SMITH" To: "Carl Tuttle" Cc: "CHAN FUNG, Margaret F.C." , asamoa-baaha@who.int, "Raymond Bruce J. AYLWARD" , "Flavia BUSTREO" , "Oleg CHESTNOV" , "Keiji FUKUDA" , "Hajime INOUE" , "Marie-Paule KIENY" , minghuir@who.int, "Hans TROEDSSON" , ramanan@cddep.org Sent: Saturday, July 16, 2016 3:23:05 PM Subject: RE: Who’s Global Action Plan on Antimicrobial Resistance Dear Sir, Thank you for highlighting this issue; antimicrobial resistance (AMR) is a grave threat, putting at risk the progress the world has made in controlling and treating many infectious diseases, including Lyme disease. WHO takes this very seriously, and has made AMR a high priority for global action. Regards, Dr Ian Smith Executive Director I Office of the Director-General I World Health Organization Office: + 41.22.791.25.36 I Mobile: +41.79.249.35.21 Email: smithi@who.int 2nd email to the World Health Organization: __________________________________________________________________________ From: Carl Tuttle [mailto:runagain@comcast.net] Sent: 18 July 2016 15:03 To: SMITH, Ian Michael Cc: CHAN FUNG, Margaret F.C.; asamoa-baaha@who.int; AYLWARD, Raymond Bruce J.; BUSTREO, Flavia; CHESTNOV, Oleg; FUKUDA, Keiji; INOUE, Hajime; KIENY, Marie-Paule; minghuir@who.int; TROEDSSON, Hans; ramanan@cddep.org Subject: Re: Who’s Global Action Plan on Antimicrobial Resistance On July 16, 2016 Dr Ian Smith wrote: “…..antimicrobial resistance (AMR) is a grave threat, putting at risk the progress the world has made in controlling and treating many infectious diseases, including Lyme disease.” Dear Dr Smith, Thank you for responding to my email. Question: What exactly is the World Health Organization doing regarding antimicrobial resistance in the treatment of Lyme disease? I have not seen any announcements from your organization identifying the need for new antimicrobials for this tick borne disease. Furthermore, it appears that antimicrobial resistance has been known for decades as Klempner reported in 1992. J Infect Dis. 1992 Aug;166(2):440-4. Fibroblasts protect the Lyme disease spirochete, Borrelia burgdorferi, from ceftriaxone in vitro. Georgilis K1, Peacocke M, Klempner MS. Author information 1Department of Medicine, New England Medical Center, Boston, Massachusetts. Abstract The Lyme disease spirochete, Borrelia burgdorferi, can be recovered long after initial infection, even from antibiotic-treated patients, indicating that it resists eradication by host defense mechanisms and antibiotics. Since B. burgdorferi first infects skin, the possible protective effect of skin fibroblasts from an antibiotic commonly used to treat Lyme disease, ceftriaxone, was examined. Human foreskin fibroblasts protected B. burgdorferi from the lethal action of a 2-day exposure to ceftriaxone at 1 microgram/mL, 10-20 x MBC. In the absence of fibroblasts, organisms did not survive. Spirochetes were not protected from ceftriaxone by glutaraldehyde-fixed fibroblasts or fibroblast lysate, suggesting that a living cell was required. The ability of the organism to survive in the presence of fibroblasts was not related to its infectivity. Fibroblasts protected B. burgdorferi for at least 14 days of exposure to ceftriaxone. Mouse keratinocytes, HEp-2 cells, and Vero cells but not Caco-2 cells showed the same protective effect. Thus, several eukaryotic cell types provide the Lyme disease spirochete with a protective environment contributing to its long-term survival. _____________________ The following letter addressed to the Centers for Disease Control was submitted through the Washington DC office of New Hampshire Senator Jeanne Shaheen. The CDC refuses to answer the questions highlighted in yellow and refuses to acknowledge antimicrobial resistance. There is more than enough evidence presented in this letter to warrant a serious investigation. Sincerely, Carl Tuttle Hudson, NH USA Letter to the Centers for Disease Control: _______________________________________________________________ April 12, 2016 Senator Jeanne Shaheen 506 Hart SOB Washington, DC 20510 Dear Senator Shaheen, I attended a meeting on March 23, 2016 where I listened to the personal stories of six professional women from New Hampshire who had to resign from their positions due to the debilitating affects of Lyme disease. Some of these women were teachers, principals etc. who had to cut short their careers. Fifth-grade teacher Kelly Downing was paralyzed from the neck down and interviewed by Katie Couric. You can read about her ordeal here: 1. http://patch.com/new-hampshire/nashua/nashua-mom-talks-chronic-lyme-on-katie-couric-show This life-altering/life-threatening experience with Lyme disease is not unique as we have similar stories all across America: 2. Professor Neil Spector: Duke physician uses near-death experience to encourage patient self-advocacy Dr Neil Spector from Duke University required a heart transplant after his Lyme disease went undiagnosed for four years. http://www.dukechronicle.com/articles/2015/05/28/duke-physician-uses-near-death-experience-encourage-patient-self-advocacy#.VYlYnxtViko 3. Wheelchair-Bound Girl Calls Blessing By Pope Francis ‘Most Precious Moment Of My Life’ NEW YORK (CBSNewYork) — A 12-year-old girl who has been confined to a wheelchair since being diagnosed with Lyme disease said meeting Pope Francis as he arrived in New York Thursday was “the most precious moment of my life.” Source: http://newyork.cbslocal.com/2015/09/24/pope-francis-blesses-girl-in-wheelchair/ 4. Scotty Shelton and Persistent Infection in Saginaw MN https://www.change.org/p/the-us-senate-calling-for-a-congressional-investigation-of-the-cdc-idsa-and-aldf/u/11685820 “Scotty's brain (cerebral cortex) was positive for Borrelia burgdorferi and Borrelia myamotoi, his testicle is positive for Bb. We are now testing other tissues. Seven years of antibiotics and 3.5 years of natural treatments (along with antibiotics) and he was highly highly positive.” 5. Cardiac Tropism of Borrelia burgdorferi: An Autopsy Study of Sudden Cardiac Death Associated with Lyme Carditis. (March 2016) http://ajp.amjpathol.org/article/S0002-9440(16)00099-7/abstract Excerpt: “Fatal Lyme carditis caused by the spirochete Borrelia burgdorferi rarely is identified. Here, we describe the pathologic, immunohistochemical, and molecular findings of five case patients.” 6. Yolanda Foster: Yolanda Foster on Lyme Disease: I've Lost Ability to Read, Write, Watch TV http://www.usmagazine.com/celebrity-news/news/yolanda-foster-on-lyme-disease-ive-lost-ability-to-read-write-2015191 7. Amy Tan: SLyme Disease: How A Speck Changed My Life Forever http://www.humanthology.com/lyme-disease/2014/9/15/slyme-disease-how-a-speck-changed-my-life-forever 8. Averil Lavine: Avril Lavigne Opens Up About Her Health Crisis: 'I Was Bedridden for 5 Months' http://www.people.com/article/avril-lavigne-lyme-disease-bedridden 9. CDC Case Study #1: Three Sudden Cardiac Deaths Associated with Lyme Carditis: http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6249a1.htm?s_cid=mm6249a1_w 10. CDC Case Study #2: A case report of a 17-year old male with fatal Lyme carditis http://www.cardiovascularpathology.com/article/S1054-8807(15)00025-3/abstract?rss=yes ________________________ There are roughly 700 scientific articles supporting chronic Lyme disease or persistent Borrelia infection: (suppressed scientific evidence) Peer Reviewed Evidence of Persistence of Lyme Disease Spirochete Borrelia burgdorferi and Tick-Borne Diseases after the mandated one-size-fits-all IDSA treatment approach: http://www.ilads.org/ilads_news/wp-content/uploads/2015/09/EvidenceofPersistence-V2.pdf It appears that we have been dealing with an antibiotic resistant/tolerant superbug: 1. Researchers’ discovery may explain difficulty in treating Lyme disease http://www.northeastern.edu/news/2015/06/researchers-discovery-may-explain-difficulty-in-treating-lyme-disease/ Excerpt: “North¬eastern Uni¬ver¬sity researchers have found that the bacterium that causes Lyme disease forms dor¬mant persister cells, which are known to evade antibi¬otics.” 2. Standard antibiotic treatment for Lyme disease does not kill persistent Borrelia bacteria. http://droopyyoupi.blogspot.com/2015/08/standart-antibiotic-treatment-for-lyme.html -What has tuberculosis and Borrelia burgdorferi in common? In the late stage of the disease occurs persistent (tolerant) bacteria, which essentially means that the bacteria lasts and lasts and lasts. They protect themselves against antibiotics and are difficult to treat. - Both Borrelia burgdorferi and tuberculosis is relatively easy to cure in the early stages, even with the use of one antibiotic. In the late stage it is impossible to cure the disease with the same type of treatment in the acute phase, said Dr. Ying Zhang when he visited the year NorVect conference. -Dr. Ying Zhang is a professor at the Department of Molecular Microbiology and Immunology at the Johns Hopkins Bloomberg School of Public Health 3. Evidence of in vivo existence of Borrelia biofilm in borrelial lymphocytomas http://wtnh.com/2016/02/23/unh-discovers-biofilm-in-those-affected-by-lyme-disease/ Excerpt: “An article by a UNH research team led by Professor Eva Sapi is the first to show that the microorganisms that cause Lyme disease are resistant to treatment due to what’s called a biofilm. A biofilm – which has a protective layer of “slime” – allows the organisms to hide away from antibiotics at the microscopic level.” _________________ We acknowledge drug-resistant bugs as a major health problem; methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), multi-drug-resistant Mycobacterium tuberculosis (MDR-TB), Neisseria gonorrhoeae and Klebsiellapneumoniae carbapenemase-producing bacteria (KPC). The CDC awarded Dr Gary Wormser of New York Medical College 1.5 million taxpayer dollars which downplayed the seriousness of Lyme disease as his study excluded the sickest of patients focusing on the acute stage of disease after early treatment. You would not see a cancer study where stage IV cancer patients are deliberately excluded. Patients who had a prolonged exposure to the spirochete before diagnoses and initial treatment are almost always incapacitated as described earlier. This class of patient has been deliberately ignored as the focus has always been on the acute or early stage of disease. Wormser has misclassified Lyme as a “nuisance” disease; easily treated and cured with a one-size-fits-all IDSA treatment approach with only a small percentage experiencing minor aches and pains after treatment; “Post Treatment Lyme Disease Syndrome.” The following link will take you to my complaint against Dr Gary Wormser of New York Medical College registered with the Office of Research Integrity: Scientific misconduct or criminal offense? https://www.change.org/p/the-us-senate-calling-for-a-congressional-investigation-of-the-cdc-idsa-and-aldf/u/14006106 A thirty year lack of oversight has led to a runaway plague misclassified as a simple nuisance disease while the dogma continues to be promoted by those who have controlled the narrative for the past three decades. This deception to the American people has not only caused untold pain and suffering but has influenced the nation's perceptions and the medical community’s response to Lyme disease. The medical establishment has been led to believe that “chronic Lyme” is a fictitious disease and hundreds of thousands perhaps millions of patients are left untreated/undertreated and suffering. There are no Public Service Announcements (PSA’s) informing the public that you could become horribly disabled by Lyme disease. Questions for the CDC: 1. Why would our CDC and members of the Infectious Diseases Society of America want to suppress a serious, disabling life-altering disease or, 2. Conceal an antibiotic resistant/tolerant superbug? This makes absolutely no sense at all and should be the first questions (among many) for a congressional investigation. A congressional investigation into how this life-altering/life-threatening disease has been misclassified as a simple nuisance disease for the past four decades is long overdue. Sincerely, Carl Tuttle 33 David Dr Hudson, NH 03051 Lyme Disease: Call for a “Manhattan Project” to Combat the Epidemic Raphael B. Stricker and Lorraine Johnson http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879353/ Response from The World Health Organization: ________________________________________ From: "Ian Michael SMITH" To: "Carl Tuttle" Cc: "Sylvie BRIAND" , "Dirk A. ENGELS" , "Minghui REN" , "Raymond Bruce J. AYLWARD" Sent: Monday, July 18, 2016 9:22:39 AM Subject: RE: Who’s Global Action Plan on Antimicrobial Resistance Dear Sir, I am copying my colleagues working in this area, who will be able to respond to your questions. Regards, Dr Ian Smith Executive Director I Office of the Director-General I World Health Organization Office: + 41.22.791.25.36 I Mobile: +41.79.249.35.21 Email: smithi@who.int 3rd email to the World Health Organization: ________________________________________ From: "Carl Tuttle" To: "Ian Michael SMITH" Cc: "Sylvie BRIAND" , "Dirk A. ENGELS" , "Minghui REN" , "Raymond Bruce J. AYLWARD" , chanm@who.int, asamoa-baaha@who.int, bustreof@who.int, chestnovo@who.int, fukudak@who.int, inoueh@who.int, kienym@who.int, minghuir@who.int, troedssonh@who.int Sent: Monday, July 18, 2016 12:55:13 PM Subject: Re: Who’s Global Action Plan on Antimicrobial Resistance On July 18, 2016 Dr Ian Smith wrote: “I am copying my colleagues working in this area, who will be able to respond to your questions.” Dear Dr Smith, Thank you for forwarding my inquiry to your colleagues. By way of introduction, I am the Change.org petition organizer calling for a Congressional investigation into the mishandling of Lyme disease here in the United States. The petition has generated over 34,000 signatures and 890 pages of heart wrenching comments from horribly disabled Lyme patients spanning 42 countries. Calling for a Congressional investigation of the CDC, IDSA and ALDF https://www.change.org/p/the-us-senate-calling-for-a-congressional-investigation-of-the-cdc-idsa-and-aldf Below are just nine randomly selected comments from patients disabled from Wormser’s “nuisance disease” whose junk science has been financed by the CDC: (Thousands more like these below) 1. My 16 year old daughter has late stage, neurological Lyme Disease. I have watch over the past several years as she has had to give up so much. She has stopped playing sports (basketball, soccer, and softball), dancing, eating many different foods, going to school, and even just spending time with friends. We have been to many different doctors with many different specialties looking for answers and have finally received a clinical diagnosis of Lyme Disease from two doctors who are working together to try to help her. The challenge now is to get her strong enough to endure the treatment that she is facing. We are told it may take years of treatment to get her to a reasonable quality of life. It is devastating to see my daughter struggle with all of this at a time when her friends are enjoy things like prom, graduations, and even just youth group activities while she sits at home suffering. This is a terrible disease! Catherine Weakley, Virginia Beach, VA 2. My best friend's life has been devastated by Lyme Disease for the last several years. If only her doctors had taken her concerns and symptoms seriously in the beginning and administered the proper tests, she may not have gone through so many years of pain. I accompanied her to these appointments and watched first hand as her symptoms were ignored and mis diagnosed over and over again. She has gone through years of suffering that could have been prevented had she been diagnosed at the start and given antibiotics. For the sake of her and the many others who are suffering needlessly I urge you to investigate this matter fully and support education, awareness, acceptance and action throughout the medical community. Samantha Erin Barragar, Malibu, CA 3. I have been suffering from Neurological Lyme Disease since I was 15 years old. A year and a half ago, I had a serious flare up that has left me disabled with seizures, tremors, cognitive issues, immobility, and chronic pain. The severity of this disease should not be overlooked, and warrants significant research. The outdated and immoral IDSA guidelines must be investigated for the sake of all current and future persons infected with Lyme. Our voices deserve to be heard! Caren Dandeo, Middletown, NJ 4. I'm positive for lyme and co infections and was getting better with treatment, then insurance stopped paying. I'm wheelchair bound now and cannot stand, move, or take care of myself. United HealthCare cited the CDC guidelines of 28 days of antibiotics of treatment. THAT'S NOT ENOUGH. Doug Frenz, Hudson, OH 5. I'm only 20 years old and I've suffered from Lyme Disease for the past 6 years of my life. For the first few years of my disease I went undiagnosed; doctors would tell me I was crazy, and I continued to get sicker and sicker. My 15 year old sister is also really sick with Lyme and has been for years. It breaks my heart. There has to be something serious done about this epidemic, and fast. Niki Mitchell, Binghamton, NY, NY 6. My 4 Lyme tests came back "negative" according to my PCP's. I was "negative" for 8 years while I did indeed have Lyme. When I visited 2 LLMD's they both verified that I had Lyme. Had it been caught 8 years prior it could have been cured. Instead, it spread to all parts of my body and brain. I in turn became a burden on the healthcare system and lost all of my assets. Accurate testing MUST be developed! Serenaty S, New York, NY 7. I am disabled, in a wheelchair, and currently on IV medicine to try and kill off Lyme, Babesia, and Bartonella. I am in huge debt because insurance refuses to pay for anything - not doctor visits, not medicine, nothing. Too many are sick and dying. Enough. Wendy Vogt, Redwood City, CA 8. My husband has been diagnosed with neurological lyme and the coinfections of bartonella and babesia. We spent years going form doctor to doctor trying to find out what he has. His illness reached the point where he is no longer able to work. Our insurance company will not approve the IV antibiotics he needs to get better due to the current CDC guidelines. The illness does not just affect the patient but the entire family. Lyme needs to be addressed. Kathy Wilder Bichler, Fair Lawn, NJ 9. Spent over $100,000 dollars to get our son well in Oklahoma. 21 doctors would not recognize Lyme disease because of ignorance. We went out of state to find a LLMD. It is an awful disease and in so many ways. His Lyme test only had one band positive so according to the CDC is not proof of Lyme. Well wrong...he was pulled 5 ticks off himself and 3 days later severally I'll for the next 2 1/2 years of being homebound. We where lucky we had a savings but I took our retirement money. Diana Clock, Bixby, OK Dr Smith, I would be happy to burn a copy of the comment file onto a blank DVD and mail it to you directly. The PDF file is 21MB so sending as an attachment exceeds size limitation. Sincerely, Carl Tuttle Hudson, NH USA Our legislators here in the United States and around the globe should be asking the following questions: (As world health agencies are blindly following what has been established here in the United States) “Who is responsible for misclassifying Lyme as a simple nuisance disease and why?” Lyme Disease: Call for a “Manhattan Project” to Combat the Epidemic Raphael B. Stricker and Lorraine Johnson http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879353/ 4th email to the World Health Organization: ________________________________________ From: "Carl Tuttle" To: "Ian Michael SMITH" Cc: "Sylvie BRIAND" , "Dirk A. ENGELS" , "Minghui REN" , "Raymond Bruce J. AYLWARD" , chanm@who.int, asamoa-baaha@who.int, bustreof@who.int, chestnovo@who.int, fukudak@who.int, inoueh@who.int, kienym@who.int, minghuir@who.int, troedssonh@who.int Sent: Monday, July 18, 2016 2:25:34 PM Subject: Re: Who’s Global Action Plan on Antimicrobial Resistance Dear Dr Smith, The CDC has refused to respond to the following letter regarding the sexual transmission of Lyme disease……. -------------------------------------------------------------------------------- From: "Carl Tuttle" To: "pfm0" Cc: "CDCExecSec" , "coh2" Sent: Thursday, July 14, 2016 12:32:48 PM Subject: The CDC wants your semen (if you've had Zika) The CDC wants your semen (if you've had Zika) http://www.cnn.com/2016/07/14/health/zika-semen-cdc/index.html "I'm happy to say patients really have been quite receptive about volunteering their specimens," said Dr. Paul Mead, the senior epidemiologist at the CDC who is running the study. "They seem to understand the importance of the study." July 14, 2016 Division of Vector-borne Infectious Diseases, NCEZID, CDC Centers for Disease Control and Prevention 3156 Rampart Road Ft. Collins, CO 80521 Attn: Paul Mead, Chief of Epidemiology at Centers for Disease Control and Prevention Dr Mead, With over 300,000 cases annually why are we not doing the same study for Lyme disease? NEWS: Recent study suggests that Lyme disease can be sexually transmitted https://www.lymedisease.org/lyme-sexual-transmission-2/ Excerpt: “…all women with Lyme disease tested positive for Borrelia burgdorferi in vaginal secretions, while about half of the men with Lyme disease tested positive for the Lyme spirochete in semen samples. Furthermore, one of the heterosexual couples with Lyme disease showed identical strains of the Lyme spirochete in their genital secretions.” It has become blatantly obvious that the CDC has failed miserably at managing the Lyme disease epidemic here in the United States as we are dealing with a life-altering/life-threatening disease that belongs in the same health threat category as AIDS, Zika and Ebola. Patients advancing to late stage Lyme are horribly disabled as testimonies from celebrities continue to surface. The recent Johns Hopkins study identifying Borrelia persisters (cyst formation) offers an explanation for why the late stage patient requires years of treatment. Dr Mead, ….Are you actually blind to all of this? I think we’re all astonished as to how a high ranking official at the CDC can remain in denial for so many decades. Carl Tuttle Hudson, NH Lyme Disease: Call for a “Manhattan Project” to Combat the Epidemic Raphael B. Stricker and Lorraine Johnson http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879353/ 5th email to the World Health Organization: ________________________________________ From: "Carl Tuttle" To: "Ian Michael SMITH" Cc: "Sylvie BRIAND" , "Dirk A. ENGELS" , "Minghui REN" , "Raymond Bruce J. AYLWARD" , chanm@who.int, asamoa-baaha@who.int, bustreof@who.int, chestnovo@who.int, fukudak@who.int, inoueh@who.int, kienym@who.int, minghuir@who.int, troedssonh@who.int, nord@icddrb.org Sent: Tuesday, July 19, 2016 10:14:36 AM Subject: Re: Who’s Global Action Plan on Antimicrobial Resistance July 19, 2016 World Health Organization Avenue Appia 20 1211 Geneva 27 Switzerland Attn: Ian Smith MD, Executive Director of the Director-General's Office Dear Dr Smith, In 2008 Nordin Zeidner published his study regarding single dose Doxycycline for tick bite. Pamela Weintraub interviewed Zeidner for her book: Cure Unknown (Revised Edition): Inside the Lyme Epidemic By Pamela Weintraub https://books.google.com/books?id=kEWqCFNrqt4C&pg=PA347&lpg=PA347&dq=Nordin%27s.+Zeidner&source=bl&ots=vKN7k50McS&sig=UFhzYWAEeh1PfE_7VdbH9-38DfA&hl=en&sa=X&ved=0ahUKEwi_rYefwLjJAhVIVT4KHWrZCLI4ChDoAQghMAE#v=onepage&q=Nordin's.%20Zeidner&f=false Excerpt: “Immunologist Nordin Zeidner, chief of the CDC's Vector-Host laboratory in Fort Collins, Colorado, told me internal agency studies had found the strategy questionable, and definitely ineffective in mice.” “With the support of his CDC colleagues, Zeidner had begun to work with industry to develop an alternative: a form of injectable Doxy that could be sustained in the body for nineteen days.” “Trying his formulation on mice, Zeidner found that 100 percent were protected from Lyme as well as the coinfection, anaplasmosis.” “…..single dose doxy stopped Lyme disease not in 87% of mice, but rather, in 20 to 30 percent at most.” _____________________________ Dr Gary Wormser of New York Medical College (who has controlled the Lyme disease narrative for the past three decades) published a study earlier promoting the use of single dose Doxy for tick bite. (See Wormser’s 2001 flawed NEJM article) I understand that it was Wormser who called Zeidner’s superiors at the CDC to put an end to Zeidner’s work. Zeidner was told to discard the mice sera instead of testing for antibodies as he had promised. Zeidner’s research was terminated for “lack of industrial support” Mead, and he was promoted, and his email address inactivated. A search of the HHS Employee Directory for Zeidner will show he is no longer listed. (Previous email address: Naz2@cdc.gov) The CDC stopped his research, sent him to Europe, and promoted him. There are other stories of overt intimidation, even threats of job loss for researchers who don't toe the line. I have attached Zeidner’s 2008 study for your review. Wormser’s single dose Doxycycline is still promoted today as I received a frantic call last week from a good friend in Massachusetts who was given a prescription for a single day’s supply of Doxycycline. The tick had been attached for over 72hrs. Practitioners who are experiencing the devastation of Lyme disease are prescribing 28 days. The last published paper I see for Zeidner (PubMed) looks like he now is in Bangladesh. Center for Communicable Diseases, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh AHI Officer—Nord Zeidner, DVM, PhD nord@icddrb.org What is the point to all of this you might ask? World health agencies are blindly following what has been wrongly established here in the United States as the 30yr dogma prevails while Lyme patients across the globe remain severely debilitated with no treatment options for this antibiotic resistant/tolerant superbug. Will the World Health Organization step in and upgrade Wormser’s “nuisance disease” to the serious public health threat that it represents or will the WHO turn a blind eye to all the evidence indicating (What I believe as do many others) that a serious crime against humanity has been committed? Respectfully Submitted, Carl Tuttle Hudson, NH USA Cc: AHI Officer—Nord Zeidner, DVM, PhD 6th email to the World Health Organization: ________________________________________ From: "Carl Tuttle" To: "Ian Michael SMITH" Cc: "Sylvie BRIAND" , "Dirk A. ENGELS" , "Minghui REN" , "Raymond Bruce J. AYLWARD" , chanm@who.int, asamoa-baaha@who.int, bustreof@who.int, chestnovo@who.int, fukudak@who.int, inoueh@who.int, kienym@who.int, minghuir@who.int, troedssonh@who.int, nord@icddrb.org Sent: Wednesday, July 20, 2016 8:02:37 AM Subject: Re: Who’s Global Action Plan on Antimicrobial Resistance July 20, 2016 World Health Organization Avenue Appia 20 1211 Geneva 27 Switzerland Attn: Ian Smith MD, Executive Director of the Director-General's Office Dear Dr Smith, I would like to call attention to the following article quoting Dr Kenneth Liegner who has been treating Lyme disease exclusively for decades in the State of New York. Despite months and months of treatment, his patient, Vicki Logan received a positive culture test performed by the Centers for Disease Control. I have attached a copy of Vicki Logan’s lab results for your review. Persistent Lyme Infection 1991 LIEGNER CALL FOR REBELLION ON PART OF LYME DISEASE PATIENTS http://lookingatlyme.blogspot.com/2013/05/liegner-call-for-rebellion-on-part-of.html Excerpt: “In 1991 the Lyme disease organism, Borrelia burgdorferi, was grown from the cerebrospinal fluid of my patient Vicki Logan at the Centers for Disease Control in Fort Collins, Colorado despite prior treatment with intravenous antibiotics. Her case made the front page of the New York Times Science Times in August of 1993.” _______________________ When he reported to Dr. Liegner the CDC's positive culture for B. burgdorferi from Vicki Logan's spinal fluid despite her having received 21 days of IV cefotaxime and 4 months of oral minocycline, Dr. David Dennis, of the CDC inquired of Dr Liegner whether he had culturing capability for borreliae in his office (which he did not). The implication was that perhaps, deliberately or unwittingly, Dr. Liegner may have contaminated the specimen with live borrelia being grown in his office. Evidently, Dr Dennis had a hard time conceptualizing that borrelia (Lyme bacteria) could be isolated in culture despite such intensive antibiotic treatment. Vicki Logan’s positive culture test should have set off a red flag but was ignored while the focus remained on discrediting the sick and disabled Lyme patient population. We have Lyme support groups in every State across America with nineteen in Pennsylvania alone. These support groups help the sick and disabled Lyme patient navigate a medical community practicing willful ignorance misguided by the CDC, IDSA and American Lyme Disease Foundation. Until we have a routine lab test to gauge treatment failure or success in all stages of disease, these arguments regarding long term use of antibiotics are irrelevant. In fact, the antibiotic debate is a distraction from what should be the priority here; finding new antimicrobials capable of eradicating the spirochete and its persisters. If we can’t prove that the pathogen is present, how can we possibly insist that it isn’t? There is far too much evidence (Vicki Logan’s positive CDC culture test etc.) to ignore that we are dealing with an antibiotic resistant/tolerant superbug. We are three decades into this 21st Century plague with absolutely no end in sight and no cure. It has become blatantly obvious that the focus right now in the United States is to insure that the 30yr dogma remains intact. Will the World Health Organization step in and focus on a cure for persistent Borrelia infection or will the world’s health authority ignore all the evidence that Lyme disease has been horribly, horribly mishandled? A response to this inquiry is requested. Sincerely, Carl Tuttle Hudson, NH USA Dr Kenneth Liegner’s book: In the Crucible of Chronic Lyme Disease http://www.inthecrucibleofchroniclymedisease.com/ “We are in the midst of paradigm change,” Dr. Liegner said. “Improved methods of diagnosis, treatment and prevention are urgently needed” NOTE: SEVEN ADDITIONAL EMAILS WILL BE POSTED TOMORROW AS CHANGE.ORG LIMITS THE SIZE OF UPDATES