©Photo by Allef Vinicius (Unfiltered). 

Unmasking the Destructive Force of Toxic Fumes
Higher Sensitivity Rates Found in Women

By Bearnairdine Beaumont
09 June 2024

‘The unregulated flow of unfiltered and recycled toxic fumes coming from a mix of pyrolyzed jet fuel and engine oils into the cabin-breathing air is causing many flight safety and health issues for cabin crew, pilots, and passengers. Aerotoxic Syndrome.

Over time, regular exposure to polluted breathing air can lead to health problems. When seeking help, symptoms are often not visible (anymore) and doctors don't have an obvious explanation. Nor do they usually think of ‘poisoning’ and even dismiss the symptoms as "not real" or "psychological" - I don’t know which is worse.
The chemical fumes to which crews are regularly exposed can cause (acquired) chronic illness. Many experts agree that even so-called "low levels" of chemicals can cause symptoms of varying intensity, from mild to debilitating. Toxic substances can affect the central nervous system and brain, the respiratory and gastrointestinal systems, and even the skeletal-muscular system. The eyes and ears can also be affected, causing acute visual impairment and chronic hearing loss. These symptoms are increasingly known in the aviation industry as "aerotoxic syndrome". Aerotoxic Syndrome can be compared to "Multiple Chemical Sensitivity" (MCS) or "Toxicant-induced loss of tolerance" (TILT) as they share similar signs and symptoms and have similar triggers. These chemically induced conditions also appear to have a female predominance.

Women are more likely to be sensitive
A study led by epidemiologist Gail McKeown-Eyssen of the University of Toronto suggests that the condition may indeed have a genetic basis.
The study (published in the International Journal of Epidemiology in October 2004) examined genetic differences between women who reported multiple chemical sensitivities and those who did not. The researchers recruited 203 cases and 162 controls from female respondents. They identified multiple chemical sensitivity cases using criteria derived from previous studies, including one by James R. Nethercott. Nethercott defines cases as those with chronic symptoms associated with low-level exposure to chemical agents, and resolve with the removal of exposure.
Women with higher levels of cytochrome P450 2D6, an enzyme encoded by the CYP2D6 gene, are three times more likely to be chemically intolerant than those with the inactive form of the gene. These enzymes work primarily in the liver to detoxify a wide range of chemicals, including caffeine and prescription drugs.
It is also highly expressed in areas of the central nervous system, including the 'substantia nigra', a structure in the mid-brain.

There is considerable variation between individuals in the efficiency and amount of this particular enzyme produced. Therefore, chemicals metabolized by CYP2D6 are metabolized rapidly in some people and slowly in others.

Slow metabolizers are three times more likely to have chemical intolerance than fast metabolizers. Similarly, women with the so-called fast acetylated form of NAT2, the gene that codes for an enzyme that activates both drugs and carcinogens, were four times more likely to report chemical intolerance.
Because the metabolism of some chemicals can produce toxic byproducts (metabolites), people with fast metabolisms could accumulate toxic compounds in their bodies more quickly. "It depends on the compound, what the metabolites are, and how quickly they're cleared from the body, whether having a fast metabolism results in more exposure or less exposure," says McKeown-Eyssen.
People who suffer from chemical intolerance report a wide range of symptoms, including headaches, short-term memory problems, confusion, fatigue, depression, irritability, and breathing difficulties. All of these symptoms and more are reported by affected flight crews and, increasingly, by (frequent) flyers who have been exposed to an (acute) fume event.
It is important to understand that an 'acute' fume event can trigger symptoms that have been dormant for a long time. This means the body's toxic load has been building up until it can take no more. Aircraft crews in particular would be prone to such "out of the blue" moderate to severe reactions. They often express surprise because they were unaware that their bodies had been absorbing and storing small doses of toxic substances over a long time. They may have previously dismissed minor symptoms. What happens now is TILT = the loss of tolerance to toxins - even to minute amounts.

The team around Shahir Masri at the Public Health Department, University of California, published a paper in May 2021, stating that: 

“Mixed volatile and semi-volatile organic compounds (VOCs and SVOCs), followed by pesticides and combustion products were most prevalent across TILT initiation events. As a broader category, synthetic organic chemicals and their combustion products were the primary exposures associated with chemical intolerance. Such chemicals included pesticides, peroxides, nerve agents, anti-nerve agent drugs, lubricants and additives, xylene, benzene, and acetone.” sic - / bold by BB)

Back to the Toronto researchers around Gail McKeown-Eyssen who found that individuals are likely to have certain conditions in several different forms, in one or both of the two genes with the codes: CYP2D6 and NAT2. The latter two codes for enzymes that metabolize pharmaceutical chemicals that target the central nervous system, including antidepressants, neurotoxic substances that become carcinogenic when metabolized, and even the body's neurotransmitters. NAT2 also plays a role in metabolizing several drugs and toxic chemicals, including aromatic amines - a "simple aromatic amine" is benzene.
The researchers found an even stronger association in women with the fast metabolizing form of both CYP2D6 and NAT2. These women were 18 times more likely to suffer from multiple chemical sensitivities than controls, research is ongoing.

Andreas Kortenkamp and his team state in their paper Low-Level Exposure to Multiple Chemicals: Reason for Human Health Concerns?: “The widely held view that mixtures of dissimilarly acting chemicals are “safe” at levels below NOAELs is not supported by empirical evidence. We show that this view is also based on the erroneous assumption that NOAELs can be equated with zero-effect levels. Thus, on the basis of published evidence, it is difficult to rule out the possibility of mixture effects from low-dose multiple exposures.” (sic)

Long-term and permanent debilitating health problems as a result of chronic exposure to neurotoxic, fertility, and DNA-damaging carcinogenic chemicals are increasing. Aerotoxic Syndrome, an occupational hazard of aviation, can lead to chronic chemical sensitivity, among other debilitating immune disorders, and is experienced by countless flight crew members.
Aerotoxic Syndrome is legitimate and deserves to be properly recognized by doctors, the aviation industry, and, most importantly, employers' liability insurers.’
https://bee572.substack.com/p/unmasking-the-destructive-force-of

Broken Britain’s death-dealing culture of denial, delay and deceit exposed: from government-imposed sheep dips to the infected blood scandal

’From the 1970’s until the late 1980’s it was compulsory for farmers in the UK to dip sheep twice a year with OPs (12). Many farmers who used the regulation sheep dip were later diagnosed with chronic illnesses such as multiple sclerosis (Inside Conveyancing).
Richard Bruce whose health was seriously affected by organophosphate poisoning while working as a farm manager many years ago, now spends time raising awareness about the dangers that can be presented by organophosphate pesticide exposure, and how difficult it can be to seek medical treatment after the fact (Technology Networks).
He wrote: “The reality is that when the public come knocking on the doors of this Chamber seeking justice the Government only ever answers when they have no options left”.
He cited cases involving asbestos, thalidomide, Gulf War Syndrome, Aerotoxic Syndrome, OP poisoning, Covid, vaccine damage, breast and mesh implants, pesticides, radiation, fluoride, mercury, lead and sewage pollution, commenting:
“Always the system protects itself and cares not a jot for the health of the population” 

“Scandals were in plain sight for decades while governments played for time”
Though Robert Shrimsley’s FT report mentioned the sadness of the health secretary in 1987 at the harrowing stories of the haemophiliacs who caught HIV from transfusions of infected blood, he notes that it took 25 years for his successor to report the Treasury’s blocking tactics adopted for fear of the cost of compensation (Factor 8 scandal).
While Great Britain was denying responsibility, hiding the truth and doing all it could to avoid paying compensation other countries were more honourable:
 • Canada set up a Royal Commission in 1993 and
 • Ireland established a tribunal and compensation scheme in 1997
 • and France prosecuted its premier, ministers and officials in 1999.

Sir Brian Langstaff: ‘This disaster was not an accident.’ (Guardian)
Shrimsley regarded this ‘episode’, recorded in The Langstaff reports as the worst of many episodes, from the Post Office prosecutions to the Windrush affair, highlighting defensiveness, denial and delay and years of deceit, destruction of documents and indifference as the NHS, department of health officials, ministers and prime ministers closed ranks.
The reports found that their actions were driven by a wish to avoid exposing the NHS to legal liability and, above all, the desire to save money.
He pointed out that in 2020, even when it was clear that a public inquiry forced after 22 Conservatives rebelled would lead to a compensation scheme, ministers continued to delay, pushing the costs into another year and perhaps another government.
He notes that similar patterns were seen in the case of the sub-postmasters: Post Office leaders suppressed information and the ‘walls of obstruction’ were only breached by investigative journalism, individual MPs and — in the case of the Post Office — a TV dramatisation.

A 2021 report into a decades-old murder case found that senior Metropolitan Police officers also had obstructed the new inquiry to safeguard the force’s reputation. Shrimsley (right) comments that when the state gets something wrong:
“An institutional defensiveness kicks in until the failure can no longer be denied. Money must be saved, accountability must be dodged, faith in the institution cannot be jeopardised”
Many, including shepherds, pilots, farmers and soldiers, have also suffered from what Langstaff describes as an institutional groupthink which hides the truth “to save face and to save expense”.
Shrimsley concludes that the Langstaff recommendations might help but adds: “This is a battle with a culture which has not altered in decades”. ‘
https://politicalcleanup.wordpress.com/2024/06/07/broken-britains-death-dealing-culture-of-denial-delay-and-deceit-exposed-from-government-imposed-sheep-dips-to-the-infected-blood-scandal/

The poisoning of innocent people from exposure to chemical mixtures containing Organophosphates is another disaster which could have been stopped. 
- It’s a massive scandal yet to be exposed. 

For further information on Aerotoxicity and Aerotoxic Syndrome visit -
https://www.unfiltered.vip/

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