Vi prego di copiare la lettera inviarla facendola girare agli ospedali americani o inglesi o aistraliani x trovare chi puo fare la terapia t-car x mio figlio matteo che in italia ci dicono non gli puo' essere fatta perche' nn rientra nei parametri della sperimentazione risposta al coveri3@gmail.com o 00393473187703 To the General Manager To the Medical Director hospital Dear Sir My name is Dr. Alessandro Coppini. I am a consultant in palliative care. I am at present taking care of M.C, aged nine. This young patient is affected with a neuriblastoma. The medical treatments and therapies administered, have, so far shown no satisfactory results. The rest of the consultants involved in this case believe that none of the treatments currently available in Italy would be able to help further. Given the situation I was wondering whether you would be willing to make available and provide us with t-car cell terapy there and also inibithor like "curaxin cb137 '" or ensartinib tested or during testing that in italy are not avalable to reduce metastasi to be used as part of a compassionate treatment option. Please see below a brief clinical report. We are, of course, available to provide any further information as required. Thank you in advance for your cooperation and understanding. Looking forward to hearing from you at your earliest. Kind regards, Dr. Alessandro Coppini MD Consultant in Palliative Care Florence; ITALY       Patient affected by right adrenal gland neuroblastoma. In October 2016 he had emergency surgery (post operative diagnosis revealed breaking) and chemotherapy following SIOPEN high risk treatment (8 cycles COJEC+2TVD+1ICE). The results showed a very good partial response(VGPR) and a radiometabolic therapy were then given ( Dicember 2017). After that treatment , clinical conditions were stable with residual disease in the right peri renal area , in the peraorto-cavali lympho nodes  and with some minimal possible signs of disease in units VII and VIII of Glisson's capsule(liver). The child developed pancytopenia with peripheral stem cell rescue. During the completion surgery (February-March 2018) the child complained pain of the right hip (8 March). The TC showed an increase of the right peri renal lesions and of the lymphadenopathy that were extended to liver's ilo and behind the head of pancreas. It also showed a further involvement of units VII and VIII in his liver with a suspected involvement of muscles of the lateral wall on the right thoracoabdominal side. At the moment haematological values are: 450 white blood cells, Hb 6,3 g/dl, platelets 8000. His pain is under control with Targin therapy; it allows him to do daily activities conformed with his age. In 12/03 he had 1 unit of blood (GRC). In his medical history he developed a klebsiella pneumonia infection( intermediate susceptibility); from September 2017 he is treated with posaconazolo as prophylaxis. Blood culture is ongoing(22/06). Rectal swab negative (22/06). There are metastasis at lungs 40 metastasi 2.2 centimeters and one metastasi at  sacral loins vertebrae 3 and infiltrated marrow +  and N-myc amplification is negative. Pls revert asap 00393473187703 coveri3@gmail.com