When I had my Tysabri IV reinstated I did incredibly well, my mobility improved ten-fold, as had my fatigue, pain, and also mental health.

Regardless of this, I was still told I was secondary progressive (SPMS), due to the worsening of my MS when I was moved onto Tyruko.

I was also told I had atrophy of my spine (this was terrifying), which is a big indicator for being SPMS.

So I began a treatment for SPMS in December, and once again I have dramatically declined. (I can barely walk any longer.) 

This pattern of my MS activity didn't make sense to me, I still questioned am I really SPMS?

I started to believe this, but a small part of me did wonder if this was wrong still.

So, I sought out a second opinion of a private Neurologist, that has knowledge of Tysabri and tyruko.

From my MRI scans, notes and my timeline øf events, the private Neurologist said he can, and his team without doubt, diagnose me as still being RRMS, and not SPMS.

Clinically, they could clearly see this by the behaviour of my MS:

• Tysabri IV - 2010 to March 2024. I did amazingly well.
• Tysabri Sub-cut - April-Nov 2024. Slowly worsening of MS.
• Tyruko - Dec 2024- June 2025. Dramatic deterioration.
• Tysabri IV reinstated - July-Dec 2025.  Doing remarkably well, notably, my mobility improved dramatically again. 
• Siponimod treatment - Dec 2025 to present. This is a medication licensed for SPMS. I am deteriorating at a fast rate once again. Because I shouldn't be on this drug.
  
  Also, very importantly, he looked and said that they could not agree that I have atrophy of my spinal cord. Which was one part of my current “EVIDENCE” to diagnose me with SPMS.

So, hearing this, I couldn't quite believe that I was sitting there listening to a neurologist agree with everything I have been practically screaming out to my current hospital.

My hospital had the view that both formulations of this drug (natalizumab), are no different, therefore has no correlation with my deterioration. I have sent my new second opinion for them to review.

Meanwhile, there are hospitals in the UK, that will not switch other patients to Tyruko, or are switching people back onto Tysabri IV. This is very promising.

To save money, I, and hundreds of other MS patients, are being made to rot away because of  NHS saving plans. Looking at the bigger picture, the amount they save, for our suffering, is so negligible