The government and Vertex were unable to reach an agreement yesterday, meaning that Orkambi has not been approved for the PBS in Australia. Cystic Fibrosis is the most common chronic illness in Australian children. Orkambi is providing CF sufferers with an opportunity for an improved quality of life and normalises some lung functions. Without the PBS approval, this drug will not be accessible for the majority of Australians as it is too expensive.  Vertex needs to understand the impact this drug would have on Cystic Fibrosis sufferers and just how devastating this news has been on not only people with CF, but families, friends, loved ones and supporters. Something needs to change!