Please see the letter below regarding Dr. Horowitz’s recent laboratory findings on the effects of dapsone and intracellular antibiotics as a possible treatment for this antibiotic resistant/tolerant superbug responsible for chronic Lyme disease.
---------- Original Message ----------
From: CARL TUTTLE <runagain@comcast.net>
To: "tickbornedisease@hhs.gov" <tickbornedisease@hhs.gov>
Cc: (97 Undisclosed recipients)
Date: 10/01/2020 8:51 AM
Subject: Effect of dapsone alone and in combination with intracellular antibiotics against the biofilm form of B. burgdorferi
To the Tick-Borne Disease Working Group,
When will our public health officials stop denying that we’re dealing with an antibiotic resistant/tolerant superbug?
Where is the GOVERNMENT DRIVEN MANHATTAN PROJECT to find a cure?
BMC Research Notes
Published: 29 September 2020
Effect of dapsone alone and in combination with intracellular antibiotics against the biofilm form of B. burgdorferi
Richard I. Horowitz, Krithika Murali, Gauri Gaur, Phyllis R. Freeman & Eva Sapi
https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-020-05298-6
Excerpt:
Several theories to explain persistent symptoms have been suggested, including immune evasion in privileged sites [14], antigenic variation [15], persistent antigenic stimulation [16], biofilm formation [17, 18] and B. burgdorferi persister cells, a highly resistant bacterial form which may protect the bacteria from antibacterial therapy. B. burgdorferi can exist in spirochetal, round body forms, intracellularly, as well as in newly discovered biofilm forms [4, 19,20,21,22,23,24,25,26,27,28,29]. Previous data suggested that standard and some newly discovered antibiotics for Lyme disease can be very effective in eliminating spirochetal, round body, intracellular and antibiotic tolerant persister cells [4, 20, 25,26,27] but have little effect on biofilm forms [24, 30]. Persisters are multi-drug tolerant cells present in significant numbers in biofilms [27, 29], and the importance of Borrelia biofilms has been highlighted in autopsy tissues from a well-documented Lyme disease patient [31]. Therefore, to successfully treat Lyme disease, there is an urgent need to find an agent or combination of antimicrobial agents which can efficiently eliminate resistant biofilm forms of B. burgdorferi.
Carl Tuttle
Lyme Endemic Hudson, NH