See the letter below regarding the recent Auwaerter publication…..

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WAKE UP AMERICA!

---------- Original Message ----------
From: CARL TUTTLE <runagain@comcast.net>
To: tickbornedisease@hhs.gov, chris.smith@mail.house.gov, pfm0@cdc.gov
Cc: (84 Undisclosed recipients)
Date: August 5, 2019 at 12:38 PM
Subject: Misdiagnosis of Lyme Disease With Unnecessary Antimicrobial Treatment Characterizes Patients Referred to an Academic Infectious Diseases Clinic 

To the Tick Borne Disease Working Group,

Please see the letter below (and attachment) addressed to Dr Paul Auwaerter, past president of the Infectious Diseases Society of America.

 ---------- Original Message ----------
From: CARL TUTTLE <runagain@comcast.net>
To: Paul Auwaerter <pauwaert@jhmi.edu>
Cc: psax@bwh.harvard.edu, jli@bwh.harvard.edu, cbusky@idsociety.org, Takaaki Kobayashi <tkobayashi@jhmi.edu>, jmstiglich@healio.com, infectiousdisease@healio.com
Date: August 5, 2019 at 11:16 AM
Subject: Misdiagnosis of Lyme Disease With Unnecessary Antimicrobial Treatment Characterizes Patients Referred to an Academic Infectious Diseases Clinic

EDITOR'S CHOICE

Misdiagnosis of Lyme Disease With Unnecessary Antimicrobial Treatment Characterizes Patients Referred to an Academic Infectious Diseases Clinic 

Takaaki Kobayashi, Yvonne Higgins, Roger Samuels, Aurasch Moaven, Abanti Sanyal,Gayane Yenokyan, Paul M Lantos, Michael T Melia, Paul G Auwaerter

Kobayashi T, et. Open Forum Infect Dis. 2019;doi:10.1093/ofid/ofz299.   Published 05 July 2019

Aug 5, 2019

The IDSA Foundation
1300 Wilson Boulevard Suite 300
Arlington, VA 22209
Attn:  Paul Auwaerter, vice chair of the IDSA Foundation

Dr. Auwaerter,

When will you be publishing a paper on the consequences of untreated Lyme disease?

In preparation of your manuscript I would like to offer the following references:

The statement below was extracted from Dr. Raymond Dattwyler’s patent:

1. United States Patent US 7.887,815 B2
http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=7,887,815.PN.&OS=PN/7,887,815&RS=PN/7,887,815

Dattwyler et al. Feb. 15, 2011

“Clinically, Lyme disease is a progressive disease with a wide array of manifestations. Early diagnosis and treatment is critical to prevent progression. Late disseminated infection can be associated with permanent damage to the nervous and musculoskeletal systems.”

2. Three Sudden Cardiac Deaths Associated with Lyme Carditis — United States
http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6249a1.htm?s_cid=mm6249a1_w

3. Lyme disease: A case report of a 17-year old male with fatal Lyme carditis
http://www.cardiovascularpathology.com/article/S1054-8807(15)00025-3/abstract?rss=yes

4. Fatal Lyme carditis and endodermal heterotopia of the atrioventricular node.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2429516/

5. Fatal pancarditis in a patient with coexistent Lyme disease and babesiosis. Demonstration of spirochetes in the myocardium.
http://www.ncbi.nlm.nih.gov/pubmed/4040723

6. Lyme borreliosis as a cause of myocarditis and heart muscle disease.
http://www.ncbi.nlm.nih.gov/pubmed/1915460

7. Cardiac Lyme disease - case report - A Fatality confirmed with Autopsy PCR study
http://umaryland.pure.elsevier.com/en/publications/postmortem-confirmation-of-lyme-carditis-with-polymerase-chain-reaction%2896d9181d-9d52-4fc7-9149-287cd0123f84%29.html

Failed treatment references:

8. Seronegative Chronic Relapsing Neuroborreliosis.  
https://www.ncbi.nlm.nih.gov/pubmed/7796837

9. Vicki Logan’s CDC Fort Collins Positive CSF Culture Report: (My personal Dropbox account)
https://www.dropbox.com/s/vthfdpn7gv8bne2/Logan%20CDC%20Fort%20Collins%20Positive%20CSF%20%20Culture%20Report.JPG?dl=0

“In 1991 the Lyme disease organism, Borrelia burgdorferi, was grown from the cerebrospinal fluid of my patient Vicki Logan at the Centers for Disease Control in Fort Collins, Colorado despite prior treatment with intravenous antibiotics.  Her case made the front page of the New York Times Science Times in August of 1993.” -Kenneth Liegner, MD

Here are links to the seven page autopsy results of patient Vicky Logan showing histopathologic findings consistent with neurologic manifestations of chronic Lyme disease.

(Vicky Logan’s Autopsy results Page #1, 2, 3, 4, 5, 6, 7)
https://www.dropbox.com/s/xaul84dqmqgbre0/Brenda%20Fitzgerald%20MD%20Director%20CDC.docx?dl=0

The destructive nature of Borrelia is evident in Vicky Logan’s liver (nutmeg liver), kidneys, heart, lungs and brain. The patient died after the insurer refused additional IV antibiotic therapy

10. Persistent Borrelia Infection in Patients with Ongoing Symptoms of Lyme Disease

Published: 14 April 2018

http://www.mdpi.com/2227-9032/6/2/33

All of these patients were culture positive for infection (genital secretions, skin and blood) even after multiple years on antibiotics so there was no relief from current antimicrobials. Some of these patients had taken as many as eleven different types of antibiotics.

11. DNA sequencing diagnosis of off-season spirochetemia with low bacterial density in Borrelia burgdorferi and Borrelia miyamotoi infections. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139787/

12. Seronegativity in Lyme borreliosis and Other Spirochetal Infections (103 references)
https://www.dropbox.com/s/3d6m45jzlhhwalu/Seronegativity.pdf?dl=0

13. Peer Reviewed Evidence of Persistence of Lyme Disease Spirochete Borrelia burgdorferi and Tick-Borne Diseases (700 arrticles)
https://www.dropbox.com/s/14kogblsjc7po2x/EvidenceofPersistence-V2.pdf?dl=0

14. Congenital Transmission of Lyme Disease (28 references)
https://www.dropbox.com/s/xlju8w25phkypy0/Congenital%20Transmission%20of%20Lyme.pdf?dl=0

15. Deaths from Lyme Disease
https://www.dropbox.com/s/eo794dx7zspc1ln/Ld%20deaths.doc?dl=0

In Scientific Literature, Books, Newsletters/Newspapers/Obituary

Compiled by: John D. Scott, Research Scientist 17 April 2018

Let’s not forget Dr. Auwaerter that humans do not produce detectable antibodies to Lyme disease for 4-6 weeks after a tick bite. By the time serology tests are positive, the spirochetes have already invaded various deep tissues, like those in syphilis, and are hard to eradicate with antibiotics.

You wouldn’t want to give the impression that Lyme is a simple nuisance disease or fictitious as depicted in the attached caricature….. Looking forward to your informative paper on the “consequences of untreated Lyme disease.”

(attached caricature: https://www.dropbox.com/s/dljlsmjbvk2trur/lyme%20toon.JPG?dl=0

Sincerely,

Carl Tuttle

Lyme Endemic Hudson, NH