Dr. Auwaerter responded to yesterday’s inquiry previously posted as a Petition Update:
Today’s letter to the Tick-Borne Disease Working Group…..
(It appears that the propaganda is spreading worldwide)
-------- Original Message ----------
From: CARL TUTTLE <runagain@comcast.net>
To: tickbornedisease@hhs.gov, chris.smith@mail.house.gov
Cc: (98 Undisclosed recipients)
Date: July 3, 2019 at 7:32 AM
Subject: Response from Dr. Paul Auwaerter regarding the IDSA grant to search for an infectious cause of Alzheimer’s disease.
To the Tick-Borne Disease Working Group,
Please see the attached letter from Dr. Paul Auwaerter regarding the IDSA grant to search for an infectious cause of Alzheimer’s disease.
https://www.dropbox.com/s/rg3tfhk4kii7eq6/Auwaerter%20Response%20Alzheimer%20Research.docx?dl=0
Auwaerter immediately finds two publications to defend his overlooking of Borrelia as a possible infectious cause of Alzheimer’s disease but misses these four:
1) Pappolla MA, Omar R, Saran B, et al. Concurrent neuroborreliosis and alzheimer’s disease: Analysis of the evidence. Hum Pathol. 1989;20(8):753-757. doi:10.1016/0046-8177(89)90068-3.
2) McLaughlin R, Ng Ying Kin NMK, Chen MF, Nair NPV, Chan ECS. Alzheimer’s disease may not be a spirochetosis. Neuroreport. 1999;10(7):1489-1491. doi:10.1097/00001756-199905140-00018.
There were spirochetes found in 1 of 6 late stage AD patients. That’s not zero.
3) Marquard R, Kurz A, Bremer D, Dose M. Borrelia Burgdorferi: Risk Factor in Alzheimer’s Disease Poster Session 2 , Monday 12 September. Eur J Neurol. 2011;18 (Suppl.:345. doi:10.1111/j.1468-1331.2011.03552.x.
4) Bu X-L, Yao X-Q, Jiao S-S, et al. A study on the association between infectious burden and Alzheimer’s disease. Eur J Neurol. 2015;22(12):1519-1525. doi:10.1111/ene.12477.
My response to Dr. Auwaerter below includes a recent appalling publication in the European Journal of Pediatrics from Italy:
Somatic symptom disorder should be suspected in children with alleged chronic Lyme disease
https://link.springer.com/article/10.1007/s00431-019-03416-6
I have made an inquiry into what motivated the author to publish this rubbish and asked if any of the defendants named in the racketeering lawsuit contacted them to promote this propaganda (collusion).
My reply to Auwaerter:
---------- Original Message ----------
From: CARL TUTTLE <runagain@comcast.net>
To: pauwaert@jhmi.edu
Cc: jmstiglich@healio.com, infectiousdisease@healio.com, geriatricmedicine@healio.com, tanzi@helix.mgh.harvard.edu, Steven.Dekosky@neurology.ufl.edu, wpowderl@wustl.edu
Date: July 2, 2019 at 10:47 AM
Subject: Re: Q&A: IDSA to award $500K in search for infectious cause of Alzheimer’s disease
July 3, 2019
The IDSA Foundation
1300 Wilson Boulevard Suite 300
Arlington, VA 22209
Attn: Paul Auwaerter, vice chair of the IDSA Foundation
Dear Dr. Auwaerter,
Thank you for your rapid response informing me that there are no restrictions and researchers are welcome to submit grant requests related to Borrelia infections.
I would like to call attention to a recently published paper out of Italy which appears to be propagation of the long established dogma originating in the United States through members of the Infectious Diseases Society of America. (Now being questioned in Texas District Court)
Please see my letter below with the corresponding author of the paper titled:
Somatic symptom disorder should be suspected in children with alleged chronic Lyme disease
https://link.springer.com/article/10.1007/s00431-019-03416-6
My intention here is not to be disrespectful as I am pointing out the facts as they are/were published.
Sincerely,
Carl Tuttle
Lyme Endemic Hudson, NH
---------- Original Message ---------- From: CARL TUTTLE <runagain@comcast.net>
To: francescaperi92@gmail.com
Cc: ndemanzini@units.it, daniela.nistico@burlo.trieste.it, giuliana5morabito@gmail.it, alexander82@tiscali.it, alessandro.ventura@burlo.trieste.it, mario.bianchetti@usi.ch, ejp@spaarnegasthuis.nl
Date: July 1, 2019 at 12:15 PM
Subject: Somatic symptom disorder should be suspected in children with alleged chronic Lyme disease
European Journal of Pediatrics
Somatic symptom disorder should be suspected in children with alleged chronic Lyme disease
https://link.springer.com/article/10.1007/s00431-019-03416-6
Excerpt:
Before the diagnosis of CLD, the serology for Borrelia burgdorferi was sought in all cases (both ELISA and Western blot): IgM were positive in 2 patients, while IgG were negative in all patients. After the diagnosis of CLD, all patients received cycles of antibiotic therapies without resolution of symptoms.
July 1, 2019
University of Trieste
Piazzale Europa
1, Via dell’Istria
34127 Trieste, TS, Italy
Attn: Francesca Peri
Dear Dr. Peri,
In reference to serologic testing for Lyme disease, I would like to call attention to the recent Schutzer et al paper coauthored by Dr. Paul Mead of the US Centers for Disease Control.
Direct Diagnostic Tests for Lyme Disease (March 2019)
https://www.ncbi.nlm.nih.gov/pubmed/30307486
“Serologic tests cannot distinguish active infection, past infection, or reinfection. Reliable direct-detection methods for active B. burgdorferi infection have been lacking in the past but are needed and appear achievable”
____________
The following pilot study recently identified chronic Lyme disease in twelve patients from Canada. All of these patients were culture positive for infection (genital secretions, skin and blood) even after multiple years on antibiotics so there was no relief from current antimicrobials. Some of these patients had taken as many as eleven different types of antibiotics.
Persistent Borrelia Infection in Patients with Ongoing Symptoms of Lyme Disease
http://www.mdpi.com/2227-9032/6/2/33 Published: 14 April 2018
From Stony Brook Lyme Clinic; I understand the patient identified in the case study below received thirteen spinal taps, multiple courses of IV and oral meds, and relapsed after each one, proven by CSF antigens and/or PCR. The only way this patient (said to be a physician) remained in remission was to keep her on open ended clarithromycin- was on it for 22 months by the time of publication.
Seronegative Chronic Relapsing Neuroborreliosis.
https://www.ncbi.nlm.nih.gov/pubmed/7796837
Lawrence C.a · Lipton R.B.b · Lowy F.D.c · Coyle P.K.d
aDepartment of Medicine, bDepartment of Neurology, and cDivision of Infectious Diseases, Albert Einstein College of Medicine, and dDepartment of Neurology, State University of New York at Stony Brook, New York, NY., USA
Eur Neurol 1995; 35:113–117 (DOI:10.1159/000117104)
Abstract
We report an unusual patient with evidence of Borrelia burgdorferi infection whoexperienced repeated neurologic relapses despite aggressive antibiotic therapy. Each course of therapy was associated with a Jarisch-Herxheimer-like reaction. Although the patient never had detectable free antibodies to B. burgdorferi in serum or spinal fluid, the CSF was positive on multiple occasions for complexed anti-B. burgdorferi antibodies, B. burgdorferi nucleic acids and free antigen.
Forty one years ago Allen Steere knew that antibiotics used to treat Lyme disease were not working:
Lyme arthritis: an epidemic of oligoarticular arthritis in children and adults in three connecticut communities. (1977)
Steere AC, Malawista SE, Snydman DR, Shope RE, Andiman WA, Ross MR, Steele FM.
https://www.ncbi.nlm.nih.gov/pubmed/836338
Excerpt:
“The best treatment for this illness is not clear. Some physicians have reported that penicillin or tetracycline results in disappearance of the skin lesion (41,42), but others find antibiotics ineffective. Four of the patients with expanding skin lesions received penicillin but still developed arthritis.”
____________________________
A PubMed.gov search will find hundreds of papers reporting persistent Borrelia infection so what we are dealing with here is an antibiotic resistant/tolerant superbug and patients who have advanced to late stage are left to fend for themselves. This is an absolute public health disaster dictated by those who have controlled the narrative for the past three decades.
I have attached a list of over 700 peer reviewed articles that support the evidence of persistence of Lyme and other tick-borne diseases. It is organized into different categories—general, psychiatric, dementia, autism and congenital transmission.
As a member of the Surgical and Health Sciences Department at the University of Trieste you should be well aware of the following;
Untreated streptococcal pharyngitis can progress to rheumatic fever, causing irreversible heart damage. Untreated syphilis leads to progressive disability and dementia, and untreated human immunodeficiency virus infection progresses to AIDS with significant disability and death. What happens to a patient with Lyme disease who goes months, years, or decades before diagnosis because of a false-negative serological test result, missing erythema migrans (Bulls-eye rash) misdiagnosis etc.? You did not discuss the consequences of untreated Lyme disease in your viewpoint.
Post Treatment Lyme Disease Syndrome after early treatment and untreated late stage Lyme of months, years or decades are two distinctly different disease states with the later going unrecognized for over three decades. The absence of a bulls-eye rash after tick bite allows patients to progress to severe neurological disease instead of obtaining a prompt diagnosis and early treatment.
Patient testimony not only in America but across the globe is describing a disease that is destroying lives, ending careers while leaving its victim in financial ruin as exposed in the documentary “Under our Skin”
Under Our Skin - Extended Trailer
https://www.youtube.com/watch?v=sxWgS0XLVqw&feature=channel_page
Using one or three month trial evidence to conclude that antibiotic treatment is ineffective is also flawed, because those time points are arbitrary. And, even though it is observational evidence that longer duration treatment with certain antibiotic regimens is effective, as is the case with the treatments many clinicians have provided to thousands of patients, that evidence is extensive and cannot be dismissed. And with accumulating evidence that the bacteria persist, and can be antibiotic tolerant, those observations make a powerful case that the continuing symptoms are due to continuing infection, not any post-treatment sequelae.
Respectfully submitted,
Carl Tuttle
Hudson, NH USA
Cc: Editor-in-Chief: Peter de Winter
References:
I am including links from my personal Dropbox storage area for the following documents:
1. Congenital Transmission of Lyme
https://www.dropbox.com/s/z10em0szgpm8bll/Congenital%20Transmission%20of%20Lyme%202015.doc?dl=0
2. Evidence of Persistence-V2 (700 peer reviewed articles that support the evidence of persistence of Lyme and other tick-borne diseases)
https://www.dropbox.com/s/14kogblsjc7po2x/EvidenceofPersistence-V2.pdf?dl=0
3. Deaths From Lyme Disease
https://www.dropbox.com/s/eo794dx7zspc1ln/Ld%20deaths.doc?dl=0
4. Seronegativity in Lyme borreliosis and Other Spirochetal Infections
https://www.dropbox.com/s/3d6m45jzlhhwalu/Seronegativity.pdf?dl=0