Please see the following letter in this series of emails to the Assistant Secretary for Health. It should be obvious that the CDC is the problem not the answer.
--------- Original Message ----------
From: Carl Tuttle <runagain@comcast.net>
To: Brett.Giroir@hhs.gov, Alex.Azar@HHS.GOV, tickbornedisease@hhs.gov
Cc: (64 Undisclosed recipients)
Date: December 11, 2018 at 7:37 AM
Subject: Re: CDC Track Record for Lyme Disease
Dec 11, 2018
U.S. Department of Health & Human Services
200 Independence Avenue, S.W.
Washington, D.C. 20201
Attn: ADM Brett P. Giroir, M.D., Assistant Secretary for Health
Dear Dr. Giroir,
Please see the letter below addressed to Dr. David W. Dorward of Rocky Mountain Laboratories biomedical research facility in Hamilton, Montana.
Per the attached publication, Dr. Dorward found that the Lyme disease spirochete attaches to, invades, and kills human B and T lymphocytes (White blood cells) within an hour of mixing the two. This research took place in 1996.
Invasion and Cytopathic Killing of Human Lymphocytes by Spirochetes Causing Lyme Disease
https://pdfs.semanticscholar.org/e724/511f382012dca645d08bca107b0dbef2896e.pdf
I understand that Dr. Dorward also cooperated with the law firm involved in the class action LymeRix vaccine injury claim.
Dr. Dorward’s research team was disbanded which put an end to the Rocky Mountain Lab Lyme program and further research into how Lyme destroys the immune system.
This is additional evidence showing that the U.S. Centers for Disease Control did not want the truth known about this life-altering/life-threatening infection capable of destroying lives, ending careers while leaving its victim in financial ruin.
Once again I ask the question: “Is the mishandling of Lyme disease a result of incompetence or collusion?"
Leaving control of the management of Lyme disease in the hands of the CDC will give us another decade of unimaginable pain and suffering.
Carl Tuttle
Lyme Endemic Hudson, NH
Letter to Dr. David W. Dorward:
---------- Original Message ----------
From: Carl Tuttle <runagain@comcast.net>
To: dave.dorward@nih.gov
Cc: elizabeth.fischer@nih.gov, vinod.nair@nih.gov, bryan.hansen@nih.gov
Date: December 10, 2018 at 2:28 PM
Subject: Invasion and Cytopathic Killing of Human Lymphocytes by Spirochetes Causing Lyme Disease
Invasion and Cytopathic Killing of Human Lymphocytes by Spirochetes Causing Lyme Disease
David W. Dorward, Elizabeth R. Fischer, and Diane M. Brooks
“This work was described in part in an abstract for the 54th annual meeting of the Microscopy Society of America held in Minneapolis on 11–15 August 1996.”
Dec 10, 2018
Rocky Mountain Laboratories - National Institutes of Health
903 S 4TH ST
HAMILTON MT 59840
Attn: Dr. David W. Dorward, PhD
Dear Dr. Dorward,
I read with great interest your paper regarding the ability of Borrelia to invade and kill human lymphocytes. It is unfortunate that you weren’t able to follow-up with this research as it appears that you stumbled onto something that upset those who took control of the narrative.
I understand that Nordin Zeidner, Chief of the CDC's Vector-Host laboratory in Fort Collins, Colorado, had a similar experience when he found that single dose Doxycycline was not successful as a prophylaxis against Lyme disease in the mouse model.
Dr. Gary Wormser published a study earlier promoting the use of single dose Doxy for tick bite.
As you know, untreated streptococcal pharyngitis can progress to rheumatic fever, causing irreversible heart damage. Untreated syphilis leads to progressive disability and dementia, and untreated HIV infection progresses to AIDS with significant disability and death. What happens to the patient with Lyme disease who goes months, years or decades before diagnosis?
Gary Wormser’s fixation on the acute stage of disease with bulls-eye rash and early treatment has left hundreds of thousands of horribly sick late stage Lyme patients with no short term treatment approach. The one-size-fits-all IDSA treatment guideline is useless and inappropriate for those who miss the narrow window of opportunity for successful short term treatment.
My years of untreated Lyme however progressed to follicular lymphoma. (Cancer of the white blood cell, B-Cells specifically) A PubMed search of “Borrelia and lymphoma” will show that connection has been known for decades. If this is controversial then perform a second search using “Epstein Barr virus and lymphoma” and you will see hundreds of results. There is no disagreement within the medical community that EBV causes lymphoma. Laboratory results while under the care of Dr. Sam Donta often identified reactivated EBV so it would appear that untreated late stage Lyme is immunosuppressive allowing latent viruses to rear their ugly heads. I think if you were allowed to continue your research you most likely would have uncovered the truth.
Please take a moment to read the following emails sent as a result of the Plotkin article published in the Journal of the Pediatric Infectious Diseases Society. These emails offer an explanation for why Lyme disease has been horribly mishandled here in the United States.
Respectfully submitted,
Carl Tuttle
Lyme Endemic Hudson, NH
1. Letter to Dr. Stanley Plotkin:
--------- Original Message ----------
From: Carl Tuttle <runagain@comcast.net>
To: stanley.plotkin@vaxconsult.com
Cc: chris.smith@mail.house.gov, collin.peterson@mail.house.gov, ddutko@hanszenlaporte.com,evpdean@upenn.edu, zaoutis@email.chop.edu, JPIDS.EditorialOffice@oup.com
Date: September 19, 2018 at 9:48 AM
Subject: Lemons and Lyme by Stanley A. Plotkin
Journal of the Pediatric Infectious Diseases Society
P L O T K I N C O L U M N
Lemons and Lyme
13 September 2018
Stanley A. Plotkin
Emeritus Professor of Pediatrics, University of Pennsylvania, Doylestown
Excerpt:
“It is odd that there is a lobby against the development and deployment of a vaccine against the disease by people who think they are suffering from Lyme infection in a chronic form, the existence of which remains doubtful. They believe that the first vaccine against Lyme disease caused chronic arthritis.”
Sept 19, 2018
Perelman School of Medicine
University of Pennsylvania
3400 Civic Center Boulevard
Building 421, Philadelphia, PA 19104
Dr. Plotkin,
“It is odd” that the two principal investigators of the previous Lyme vaccines, Allen Steere for SmithKlineBeecham's LymeRix and Gary Wormser for Connaught's vaccine (which never made it to market) have been named in a racketeering lawsuit. (See attached court document)
It is believed that Lyme disease was pigeonholed into its current status by the two principal investigators of the previous Lyme disease vaccines as these investigators conceptualized a disease that would enable vaccine development.
A preventive vaccine for Lyme disease would not satisfy the FDA if a chronic persistent infection and seronegative disease exist.
The lead author of the one-size-fits-all IDSA Lyme treatment guideline (which matches the conceptualized disease) was the principal investigator of Connaught's Lyme vaccine, Dr. Gary Wormser. This is a flagrant conflict of interest. Have we been dealing with an antibiotic resistant/tolerant superbug purposely concealed to promote vaccine development?
Forty one years ago Allen Steere knew that antibiotics used to treat Lyme disease were not working:
Lyme arthritis: an epidemic of oligoarticular arthritis in children and adults in three connecticut communities. (1977)
Steere AC, Malawista SE, Snydman DR, Shope RE, Andiman WA, Ross MR, Steele FM.
https://www.ncbi.nlm.nih.gov/pubmed/836338
Excerpt:
“The best treatment for this illness is not clear. Some physicians have reported that penicillin or tetracycline results in disappearance of the skin lesion (41,42), but others find antibiotics ineffective. Four of the patients with expanding skin lesions received penicillin but still developed arthritis.”
_______________________
A PubMed.gov search will find hundreds of papers reporting persistent Borrelia infection.
I would like to point out the following 1995 case study from Stony Brook Lyme clinic. I understand the patient received thirteen spinal taps, multiple courses of IV and oral meds, and relapsed after each one, proven by CSF antigens and/or PCR. The only way this patient (said to be a physician) remained in remission was to keep her on open ended clarithromycin- was on it for 22 months by the time of publication.
Seronegative Chronic Relapsing Neuroborreliosis.
https://www.ncbi.nlm.nih.gov/pubmed/7796837
Lawrence C.a · Lipton R.B.b · Lowy F.D.c · Coyle P.K.d
aDepartment of Medicine, Department of Neurology, and Division of Infectious Diseases, Albert Einstein College of Medicine, and Department of Neurology, State University of New York at Stony Brook, New York, NY., USA
Eur Neurol 1995; 35:113–117 (DOI:10.1159/000117104)
Abstract
We report an unusual patient with evidence of Borrelia burgdorferi infection who experienced repeated neurologic relapses despite aggressive antibiotic therapy. Each course of therapy was associated with a Jarisch-Herxheimer-like reaction. Although the patient never had detectable free antibodies to B. burgdorferi in serum or spinal fluid, the CSF was positive on multiple occasions for complexed anti-B. burgdorferi antibodies, B. burgdorferi nucleic acids and free antigen.
________________________
The following pilot study recently identified chronic Lyme disease in twelve patients from Canada. All of these patients were culture positive for infection (genital secretions, skin and blood) even after multiple years on antibiotics so there was no relief from current antimicrobials. Some of these patients had taken as many as eleven different types of antibiotics.
Persistent Borrelia Infection in Patients with Ongoing Symptoms of Lyme Disease
http://www.mdpi.com/2227-9032/6/2/33
Dr. Plotkin, your commentary published in the Journal of the Pediatric Infectious Diseases Society is little more than perpetuation of a thirty year racketeering scheme to suppress evidence of persistent infection for the purpose of vaccine development. An astute fifth grader with access to PubMed could uncover this blatantly obvious charade.
Carl Tuttle
Lyme Endemic Hudson, NH
Attachment: Lyme Disease RICO Lawsuit Court Document
https://www.dropbox.com/s/18uyrli878ug51m/LymeDisease%20RICO%20Lawsuit.pdf?dl=0
Cc: Theoklis Zaoutis, MD, MSCE EDITOR-IN-CHIEF
Julie Weber-Roark MANAGING EDITOR
Attorney Daniel Dutko of Hanszen Laporte
The Honorable Chris Smith and Collin Peterson
2. Letter to the editor of the Journal of the Pediatric Infectious Diseases Society:
--------- Original Message ----------
From: Carl Tuttle <runagain@comcast.net>
To: zaoutis@email.chop.edu
Cc: stanley.plotkin@vaxconsult.com, chris.smith@mail.house.gov, collin.peterson@mail.house.gov,ddutko@hanszenlaporte.com, evpdean@upenn.edu, JPIDS.EditorialOffice@oup.com,paul.spearman@cchmc.org
Date: September 22, 2018 at 8:32 AM
Subject: Fwd: Lemons and Lyme by Stanley A. Plotkin
Journal of the Pediatric Infectious Diseases Society
13 September 2018 P L O T K I N C O L U M N
Lemons and Lyme
Stanley A. Plotkin
Emeritus Professor of Pediatrics, University of Pennsylvania, Doylestown
Excerpt:
“It is odd that there is a lobby against the development and deployment of a vaccine against the disease by people who think they are suffering from Lyme infection in a chronic form, the existence of which remains doubtful. They believe that the first vaccine against Lyme disease caused chronic arthritis.”
Sept 22, 2018
The Journal of the Pediatric Infectious Diseases Society
Oxford University Press
2001 Evans Road
Cary, NC 27513
ATTN: Theoklis Zaoutis, MD, MSCE, EDITOR-IN-CHIEF
Dear Dr. Zaoutis,
In reference to Dr. Plotkin’s statement above, please see the following excerpt from the attachedREPORT ON LYMErix prepared for the 2001 Advisary Committee Meeting:
“The people who have contacted us were, prior to vaccination with LYMErix, healthy, active and energetic. Indeed, the very reason they sought the LYMErix vaccine was their desire to preserve their healthy, active lifestyle. However, what they experienced was a dramatic degradation of their health and quality of life. As will be described below, these previously healthy individuals are now afflicted with painful, at times debilitating arthritic symptoms, including joint pain and swelling, as well as extremely severe Lyme-disease-like symptoms which have persisted to this day.”
Below is the link to the Final Judgement and Approval of the class action against SmithKline Beecham as a settlement was awarded to these individuals.
JUDGEMENT, FINAL ORDER AND DECREE GRANTING FINAL APPROVAL OF THE CLASS ACTION SETTLEMENT:
In addition please see the following study reporting adverse neurological complications:
Int J Risk Saf Med. 2011;23(2):89-96. doi: 10.3233/JRS-2011-0527.
Neurological complications of vaccination with outer surface protein A (OspA).
Marks DH1. http://www.ncbi.nlm.nih.gov/pubmed/21673416
Abstract
A wide range of neurological complications have been reported via the medical literature and the VAERS system after vaccination with recombinant outer surface protein A (OspA) of Borrelia. To explore this issue, 24 patients reporting neurological adverse events (AE) after vaccination with Lymerix, out of a group of 94 patients reporting adverse events after Lymerix vaccination, were examined for causation. Five reports of cerebral ischemia, two transient Ischemic attacks, five demyelinating events, two optic neuritis, two reports of transverse myelitis, and one non-specific demyelinating condition are evaluated in this paper. Caution is raised on not actively looking for neurologic AE, and for not considering causation when the incidence rate is too low to raise a calculable difference to natural occurence.
_________________________________
Dr. Zaoutis, to my knowledge there was no follow-up research to determine why this class of patient suffered the reaction they experienced. Is there a genetic predisposition that could give a similar reaction to the next OspA vaccine?
It would appear that Plotkin has used your journal as a pulpit to broadcast his propaganda. The peer-review process in this case was unsuccessful in determining suitability for publication.
Respectfully Submitted,
Carl Tuttle
Lyme Endemic Hudson, NH
Cc: Julie Weber-Roark MANAGING EDITOR
Attorney Daniel Dutko of Hanszen Laporte
The Honorable Chris Smith and Collin Peterson
Paul Spearman, MD, FPIDS: President, Pediatric Infectious Diseases Society