Define "Melvin Ramsay's Myalgic Encephalomyelitis (M.E.)" as own distinct disease from CFS
0 have signed. Let’s get to 1,000!
I believe that "Melvin Ramsay's "Epidemic" Myalgic Encephalomyelitis (M.E.) - Atypical Poliomyelitis" should be it's own distinct disease category; which is separate from "Chronic Fatigue Syndrome".
Post-Infectious "Inflammatory" Encephalomyelitis has been linked to Enteroviruses and particularly Coxsackie B, Epstein Barr Virus, Cytomegalovirus, Human Herpes Virus 6, Varicella Zoster Virus, Influenza, Adenovirus, Measles, Mumps, Rubella, Borrelia and Mycoplasma in the medical literature; which have all been connected to the terms Myalgic Encephalomyelitis within the UK and Chronic Fatigue Syndrome within the US; which has erroneously made these two terms synonymous with each other.
Post-Vaccination "Inflammatory" Encephalomyelitis is linked with Vaccine Injury.
Myalgic Encephalomyelitis is the "neuroimmune" and "inflammatory" neurological disease; which comes after Enteroviral "Brainstem" Rhombencephalitis and Encephalomyelitis.
Chronic Fatigue Syndrome is a group of "missed diagnosed" illnesses; which may pass the London, Oxford, Fukuda, Canadian Consensus Criteria (CCC), International Consensus Criteria (ICC), Reeves Criteria and Systemic Exertion Intolerance Disease (SEID) criteria's.
The International Consensus Criteria is merely a diagnosis of a "probable" "neuroimmune" disease not an explicit diagnosis of Myalgic Encephalomyelitis.
A HISTORY OF PSYCHIATRY MISLEADING THE PUBLIC ABOUT M.E.
CHRONIC FATIGUE SYNDROME - Oxford Definition
"Fatigue is the principal symptom: it is severe, disabling and affects physical and mental functioning; it should have been present for a minimum of 6 months during which it was present for more than 50% of the time."
"Other symptoms may be present: particularly myalgia, mood swings and sleep disturbances."
"Definite onset of symptoms, not life-long."
"Exclusions: patients with established medical conditions known to produce chronic fatigue; also patients with a current diagnosis of schizophrenia, bipolar disorder (manic depressive illness), substance abuse, eating disorder or proven organic brain disease."
THERE IS A PROVEN ORGANIC BRAIN DISEASE IN MYALGIC ENCEPHALOMYELITIS; WHICH DISQUALIFIES M.E. FROM THE OXFORD CRITERIA AND IT CAN BE LIFELONG IN CASES.
"I do agree that this terminology is unclear. It is what official bodies in the UK offer use. I apologise and agree that CFS and ME should be kept separate" - Michael Sharpe (25/04/2018), 06:41 (tweet from twitter)
Michael Sharpe on the inclusion criteria for The Pace Trial.
"That is right all participants met criteria for CFS and a subset also for (one set of) criteria for ME. All had to have fatigue as the principle complaint. I hope clear in the paper" - Michael Sharpe (the following tweet from twitter after the one above)
Michael Sharpe admitting that people who qualified for a Chronic Fatigue Syndrome by the Oxford criteria were mixed up with people with Myalgic Encephalomyelitis (M.E.) on twitter.
The viruses linked to the "epidemics" are enteroviruses. Myalgic Encephalomyelitis is an outcome of an enteroviral infection under a compromised or ineffective immune response; leading to a secondary viremia which can lead onto a persistent non-cytolytic infection within the host.
Non-Cytolytic Enterovirus - ME Pedia
"They would have excluded some of the epidemic cases yes, and rightly so. Whatever those epidemics where, they were not what we have all being calling CFS/ME for many years See section 12 of a chapter I wrote a quarter of a century ago. Still apposite" - Simon Wessely (01/05/209), 10:01 (tweet from twitter)
Simon Wessely admitting that ME is not what they have been calling CFS/ME for all of these years.
"Dr. Wessely's work was mentioned. He has expressed his dissatisfaction with the guidelines and has written to the board to this effect. It was claimed that the DSS has misrepresented his work. He had included people with Chronic Fatigue Syndromes. There were other causes of this which people had recovered with exercise, whereas ME was made worse by exercise. The board had replied to Dr. Wessely and a copy of their reply was supplied to the ME representatives at the meeting" - from a Freedom Of Information (FOI) Request released Letter from 1992
Simon Wessely knows that "enteroviruses" were being thrown about as the triggering factor of Myalgic Encephalomyelitis in the late 80's as shown in the papers below.
Myalgic Encephalomyelitis - a warning: discussion paper. (April, 1989) - Simon Wessely
Simon Wessely in this paper is trying to muddy the waters by connecting ME with affective disorders (Depression) as well as trying to introduce the idea of relabeling Myalgic Encephalomyelitis as Chronic Fatigue Syndrome even though in the 1992 FOI request letter quote above he is clearly saying that these are separate conditions.
Simon Wessely has given two talks for UNUM the insurance company. One was in London in 1995 and was about ME & CFS, the other was in 2007. This is a clear conflict of interest.
Peter White tries to justify deceiving patients into believing that they have CFS or CFS/ME knowing that ME is a very different illness; with the blind faith that it might improve recovery times from the illness even though he's admitting its considered incurable.
This fraud by misrepresentation is still going on with labeling Myalgic Encephalomyelitis (M.E.) as Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) and breaks the Fraud Act of 2006.
What is Fraud by False Representation? - Delta Net International
How M.E has historically been portrayed as within conventional medicine and by governments around the world as a result of psychiatry's influence ?
WHAT IT ACTUALLY IS...
Myalgic Encephalomyelitis (M.E.) is a chronic, inflammatory, physically and neurologically disabling immune mediated disease that presents with symptoms involving multiple bodily systems. It is frequently triggered by a viral infection or as in the case of the Incline Village outbreak a flu-like illness, it affects the central nervous system (CNS), autonomic nervous system (ANS), immune system, cardiovascular system, endocrine system, digestive system, and (neuro) musculoskeletal system.
"Melvin Ramsay's "Epidemic" Myalgic Encephalomyelitis (M.E.) - Atypical Poliomyelitis)" is caused by an "enteroviral" infection of central nervous system; which can lead to Aseptic Meningitis, Encephalitis or Meningoencephalitis, Brainstem Encephalitis, Encephalomyelitis, Hypothalamic Dysfunction, Autonomic Nervous System Disorder or Postural Orthostatic Tachycardia Syndrome (PoTS) as well as a host of other outcomes.
Canker Sores, Mouth Ulcers, Facial Rash around Mouth & Nose, Bornholm Disease, Myocarditis, Pericarditis, Enteric Hepatitis, Acute Flaccid Myelitis, Spastic Paraplegia, Whiplash, Fibromyalgia, Trapezius Myalgia, Infectious Myositis, Post-Infectious Reactive Myositis, Small-Fiber Peripheral Neuropathy, Paresthesia, Raynard's
"It should be noted that ME/CFS symptoms are comparable to those of "Post-Poliomyelitis Syndrome" (Bruno et al 1995) and that viral injury to excitable tissues, such as muscle and nerve, has the potential to alter their crucial metabolic functions. These metabolic functions include ion channel transport, mitochondrial function (Mitochondrial Encephalopathy & Myopathy) and the response to circulating neurotransmitters and neuro-hormones (Hypothalamic Hypopituitary) - the alterations are capable of persisting well after apparent recovery from a precipitating infection (Oldstone 1989)."(Taken from 5.1 Role of infection in ME/CFS/PVFS - An Exploration of the key clinical issues (2019 Edition) by Dr. Charles Shepherd & Dr. Abhijit Chaudhuri)
WHERE DID THE FIRST NOTABLE OUTBREAK START?
AND HERE'S A MORE RECENT OUTBREAK
The Royal Free Hospital outbreak was a cluster outbreak of Myalgic Encephalomyelitis at the Royal Free Hospital in London. Between July and November, 1955 292 members of the medical, nursing, auxiliary medical, ancillary, and administrative staff fell ill, of which 255 were admitted to the hospital.
The beneath symptoms suggest that it was an ENTEROVIRUS outbreak but no pathogen was found.
Severe Headache, Malaise, Lassitude, Vertigo, Pain in limbs, Nausea, Dizziness, Neck stiffness, Neck Pain, Pain in Back, Myalgia, Muscle Weakness, Cramps, Twitching, Depression, Abdominal pain, Vomiting, Diplopia, Tinnitus, Diarrhea
Swollen Lymph Nodes, Paraesthesia
"Evidence of involvement of the sympathetic nervous system (Autonomic Nervous System Dysfunction and Adrenal Dysfunction) or actual hypothalamic damage (Hypothalamic Dysfunction) was to be found in most cases. This often took the form of orthostatic tachycardia (Postural Orthostatic Tachycardia Syndrome (PoTS)) (which Leon-Sotomayor (1969) states does not occur in cases of hysteria), chilliness of the extremities with increased sensitivity to cold (Hypothyroidism/Low T3 Syndrome), circulatory impairment (Raynaud's or Hyper-coagulation) and hypothermia."
WHAT M.E. USE TO BE CALLED IN THE PAST ? (Answer: SUPERIOR POLIO: MEDIN TYPE & NEURASTHENIA)
an upper respiratory track infection, which may include "rhinosinusitis", a "sore throat", (laryngitis), (pharyngitis) or (tonsillitis - Viral Replication) or (herpangina), "croup" (breathing difficulty and harsh cough), blisters or ulcers may develop on roof of mouth, cheeks or on tongue - Cold/Flu-like Onset
or a lower respiratory track infection like (bronchitis or bronchiolitis) so a persistent "cough"; (pneumonia), (pleurisy) or (pulmonary edema) - Respiratory-like Onset
gastrointestinal disturbances including (gastroenteritis) and "nausea" and/or "vomiting" and "diarrhea" and "abdominal pain" including (gastritis) and (enterocolitis "Peyer Patches" - Viral Replication) - Gastroenteritis Onset
"acute vertigo" and "ataxia"
Accompanied by a "fever", "hyperhidrosis - excessive sweating", severe "headache", "myalgia - muscle pain" and "malaise & fatigue" and leading to "rhombencephalitis", "post-infectious encephalomyelitis" and "tinnitus: pulsatile, tonal, neurological".
leading onto "sympathetic nervous system dominance" and "tertiary adrenal insufficiency", "insomnia", "hypersomnia" and "sleep reversal" and "weight loss" then "headaches", a "stiff neck - whiplash, neck pain and crepitus", "post-infectious encephalitis, and neuroinflammation - hypersensitive primed microglia and oxidative stress" (brain fog), "myelitis", "lower back pain", "syncope post exertion crashes", "post-infectious myositis", "arthralgia", "arthritis", "myalgia", "muscle stiffness", "muscle weakness", "spastic paraplegia" and "flu-like muscle fatigue after exertion": 2020 NICE guidelines call this "profound malaise".
Spots or Rashes may or may not develop around the mouth. Exanthems of the extremities may appear in red spots, which develop into blisters, on either the hands or the feet in some cases but not in others.
Sensitivities to light known as Photophobia, to sound known as Hyperacusis or Misophonia, and to touch known as Allodynia may develop in some but not in others.
"Since the disease is so very protean in its manifestations it may masquerade as influenza, respiratory catarrh, tonsillitis, gastroenteritis, rheumatism or as some transient virus infection" - Melvin Ramsay ("Infectious Diseases" 1967 book, page 142)
Fibromyalgia, Dysautonomia's including PoTS and Mast Cell Activation Syndrome tend to be common comorbidities as well as Irritable Bowel Syndrome, Enterocolitis, Eosinophilic Colitis, Gasteroparisis, Dysmotility, Paralytic Ileus or Elhers Danlos Syndromes.
Myalgic Encephalomyelitis is a neurological disease with autonomic manifestations usually following post-infectious encephalomyelitis as the direct result of a persistent enteroviral infection; within the nervous or gastrointestinal system.
"From my experience of ME/CFS there was no psychological component whatsoever, besides which exercise, if anything, was making me worse not better. I was not deconditioned or frightened to exercise. The symptoms were more consistent with a brain tumour or multiple sclerosis." - Dr. Nina Muirhead, Dermatologist (Buckinghamshire Healthcare NHS trust)
Melvin Ramsay's "Epidemic" Myalgic Encephalomyelitis (M.E.) (also known as Atypical Poliomyelitis or Polioencephalitis: Superior Polio - Medin Type) is a subtype of a "8E49 Postviral Fatigue Syndrome" within the ICD-11 and should be seen as such as its listed as such by the World Health Organisation (WHO).
Although the World Health Organisation (WHO) listing it as "Benign" still is an abuse of language; when it has lead to deaths around the world and within the UK and has lead to disability around the world.
Deaths and M.E.
This condition should have its own distinct set of criteria; which separates the condition from other similar conditions as its own distinct disease entity.
It also should have its own treatment; which is designed to treat the symptoms; including hormonal deficiencies as well as antivirals or immune modulating drugs or techniques designed to eradicate or minimize the destruction of the viral attack on the central nervous system and subsequent outcomes of such an attack.
HYPOTHALAMIC and TRAUMATIC BRAIN INJURY mediated HYPOPITUITARISM
The hypothalamus is the control center for several endocrine functions. Endocrine systems controlled by the hypothalamus are regulated by hormone (ADH) antidiuretic, corticotropin-releasing hormone, gonadotropin-releasing hormone, growth hormone-releasing hormone, oxytocin, all of which are secreted by the hypothalamus. Damage to the hypothalamus may impact any of these hormones and the related endocrine systems. Many of these hypothalamic hormones act on the pituitary gland. Hypothalamic disease therefore affects the functioning of the pituitary and the target organs controlled by the pituitary, including the adrenal glands, ovaries and testes, and the thyroid gland.
HYPOTHYROIDISM in MYALGIC ENCEPHALOMYELITIS - LOW T3 SYNDROME or HASHIMOTOS THYROIDITIS
ADRENAL DYSFUNCTION or TERTIARY ADRENAL INSUFFICIENCY
GROWTH HORMONE DEFICIENCY
MYALGIC ENCEPHALOMYELITIS, POSTVIRAL FATIGUE SYNDROME & TRAUMATIC BRAIN INJURY
Neurosteroids and Hormone Replacement Therapy (HRT)
Low Dose Hydrocortisone (10-15 mg) can be used daily, Bioidentical Sex Hormones of Testosterone, Progesterone (10 mg for men and 20 mg for women) and Oestrogen (or injections can be used) can also be used as well as Pregnenolone (10-100 mg) and DHEA (25 mg) or 7-Keto DHEA and Growth Hormone Secretagogues as well as Thyroid drugs such as Liothyronine (25-100 mcg depending on whats optimal dose for patient) or combination of Liothyronine & Levothyroxine or combination of Liothyronine & Natural Desiccated Thyroid can be used for Euthyroid Sick Syndrome (Low T3 Syndrome); which is present in this condition because of Hypothalamic Dysfunction, Mitochondrial Dysfunction and Inflammation. Levothyroxine alone doesn't work as it just converts into Reverse T3.
The drug Clomid can also be used in this condition.
Sensitivity problems with hormone testing related to Hypothalamic Dysfunction and Hormonal Responses
A reference range is usually defined as the set of values 95 percent of the normal population falls within (that is, 95% prediction interval). It is determined by collecting data from vast numbers of laboratory tests.
"You can't determine an individuals healthy range of functioning using this equation its preposterous" - My own thoughts.
Its a "guessimate" based on the assumption that 95% of the population is healthy in a reality that doesn't exist.
Its NOT science and lacking of any common sense whatsoever.
Disturbed physiological rhythm of cortisol secretion and concentrations of T3 were significantly lower in the CFS group.
MITOCHONDRIAL DYSFUNCTION : POST-INFECTIOUS MITOCHONDRIAL ENCEPHALOPATHY & MYOPATHY
Mitochondrial myopathies are a group of neuromuscular diseases caused by damage to the mitochondria-small, energy-producing structures that serve as the cells' "power plants." Nerve cells in the brain and muscles require a great deal of energy, and thus appear to be particularly damaged when mitochondrial dysfunction occurs.
Multivitamin Powder Drinks
Pyrroloquinoline Quinone (PQQ) (20 mg) and Ubiquinol (CoQ10) (100 mg) can be used to boost Mitochondrial function.
Vitamin B3 (Niacinamide) (Sow release) (1500 mg-a-day), Acetyl-L-Carnitine (500-1,000 mg-a-day), D-Ribose (15 g-a-day) and Magnesium (300 mg-a-day for men and 350 mg-a-day for women)
The best types of Magnesium
Magnesium Threonate, Magnesium Glycinate, Magensium Malate, Magnesium Oxide, Magnesium Orotate, Magnesium Chloride, Magnesium Sulfate, Magnesium Taurate
Vitamin C (Ascorbic Acid)
N-Acetyl Cysteine (NAC), L-Glutathione Reduced, Vitamin E - Mixed Tocopherols (d-Alpha, d-Delta, d-Beta, d-Gamma), Alpha-Lipoic-Acid, Quercetin, Resveratol, Essential Fatty Acids (igennus's Vegepa Pure EPA Omega-3 560mg), Pure Form Omega Natural and Low Dose Naltrexone (LDN) can be used to tackle neuroinflammation.
Immune Modulating Drug with Antiviral qualities
Ampligen should be given a license and fast tracked because its an essential drug for M.E.
Low-Dose Naltrexone (LDN) for Inflammation and Immune Modulation
Anticoagulant (Blood Thinner) drug.
Low-Dose Heparin can be used for Hypercoagulation and Natokinase, Lumbrokinase and Serropeptidase can be used to help remove the excess fibrin from the walls of the blood vessels.
Midodrine and Fludrocortisone can be used for Autonomic Nervous System Dysfunction.
Pyridostigmine can be used for Chronic Constipation and Autonomic Nervous System Dysfunction.
DR. JOHN CHIA & MYALGIC ENCEPHALOMYELITIS (M.E.)
Equilibrant (Oxymatrine) for Enteroviruses
Immunologloblin Therapy (IVIG) for Enteroviruses
Oxygen Therapy, Ozone Therapy and Hyperbaric Oxygen Therapy can also be useful with Brain Injuries and Lactic Acidosis
Peptides likes BPC-157 can be used to heal the stomach, gut and other parts of the body as well as other Peptides can be used to ameliorate symptoms
Peptide Therapy for rejuvenation, youngevity and healing
Probiotics for dysbiosis, allergy and serotonin
These have some D-Lactate in them but they are useful probiotics.
These are useful for allergy
Studies and treatment for ME, CFS, Fibromyalgia, Traumatic Brain Injury and Lyme Disease
There needs to be research money given towards development of new enterovirus antiviral drugs; as well as new immune modulating drugs and a new polio vaccine for all of the polio viruses.
In memory of Jodi Bassett (R.I.P.)
Enteroviruses are capable of reactivating many different Infections including Epstein Barr, Cytomegalovirus, HHV-6, Varicella Zoster etc...
[Acute Disseminated Encephalomyelitis: Post-Infectious Encephalomyelitis and Post-Vaccination Encephalomyelitis]; should have its own NHS webpage
Some viral infections thought to induce ADEM include Influenza Virus, Dengue, Enterovirus, Measles, Mumps, Rubella, Varicella Zoster, Epstein Barr Virus, Cytomegalovirus, Herpes Simplex Virus, Hepatitis A, and Coxsackievirus; while the bacterial infections include Mycoplasma Pneumoniae, Borrelia Burgdorferi, Leptospira, and Beta-Hemolytic Streptococci.
Exposure to vaccines: Hepatitis B, Human Papillomavirus (HPV), Pertussis, Diphtheria, Measles, Mumps, Rubella, Pneumococcus, Varicella, Influenza, Japanese Encephalitis, and Polio vaccines have all been implicated.
The MMR vaccine has Acute Disseminated Encephalomyelitis listed in the vaccine insert as a potential risk for the immune compromised.
OTHER NEURO-IMMUNE BASED ILLNESSES
Post-Concussion Syndrome (Gulf War Syndrome) (PTSD or Post-Concussion mediated "Traumatic Brain Injury")
Mold Illness - Chronic Inflammatory Response Syndrome (CIRS)
Silicone Breast Implant Illness
Postural Orthostatic Tachycardia Syndrome (PoTS)
Ehlers Danlos Syndromes (EDS)
Post-Infectious Neuroimmune Disease (PIND) - M.E. is the result of an Enteroviral Infection; which is a subtype of the ME-ICC.
Multiple Chemical Sensitivity (MCS)
Heavy Metal Poisoning
Mast Cell Activation Syndrome (MCAS)
Small-Fiber Peripheral Neuropathy (SFPN)
"One final thing: I was diagnosed with M.E. by a consultant neurologist (Peter Behan) after becoming ill with Coxsackie B4 in 1983 - pre-Canadian clinical guidelines - with what is known as Ramsay-defined M.E.. Everyone with an interest in M.E. should read Dr. Melvin Ramsay's book, The Saga of Royal Free Disease, 1986. He says - 'The prejudice harboured against those of us who hold the view that M.E. is an organically determined disease defies rational explanation'". - Nasim Marie Jafry
"You simply cannot look at M.E. without examining this history of prejudice." - Nasim Marie Jafry
The NHS has been discriminating against people with brain injuries and disability breaking the 2010 Equality Act and 2005 Disability Discrimination Act by denying people with brain injuries appropriate medical care.
I'm of the belief that Myalgic Encephalomyelitis (M.E.), Post-Infectious Disease Syndrome (Chronic Fatigue Syndrome), Postviral Fatigue Syndrome, Post-Pregnancy Fatigue Syndrome, Post-Surgery Fatigue Syndrome, Post-Infectious or Autoimmune Encephalitis, Fibromyalgia, Toxic Encephalopathy, Post-Sepsis Syndrome, Lyme Disease, Elhers Danlos Syndromes and Post-Concussion Syndrome: Traumatic Brain Injury (T.B.I.) needs to be physically added in name terms to the Equality Act of 2010 just like M.S. and H.I.V. is there in name terms. These conditions all face a similar history of discrimination against them.
IT IS HISTORY REPEATING
The DWP has been discriminating against people with Myalgic Encephalomyelitis, Post-Infectious Disease Syndrome (Chronic Fatigue Syndrome), Postviral Fatigue Syndrome, Post-Sepsis Syndrome, Toxic Encephalopathy, Fibromyalgia, Traumatic Brain Injury and Lyme Disease by making them fight for their benefits and attempting to target this group of patients; who are severely unwell and attempting to defraud them out of their entitlements. Rejecting that they are too unwell to work. Manipulating their assessments, falsely misrepresenting their symptoms and the effect those symptoms have on them and "gaslighting" their lived experience in the interpretation of the assessments; and then making them fight them; with mandatory reconsideration's; when they have cognitive dysfunction and impairment; paralytic exhaustion and a whole host of other symptoms; sending them off to a judge and doctor to prove that they are too unwell to work and suffering from brain injuries.
THE PACE TRIAL CONTROVERSY (Scientific Fraud)
Rituximab treatment for Myalgic Encephalomyelitis is stupid.
"The possible persistence and reactivation of EV in a clinical setting is of profound importance, especially with the addition of immunosuppressive drugs, such as Rituximab, given to patients suffering from B cell lymphomas. Immunosuppression, especially with drugs targeting the humoral immune response, may lead to reactivation/increased replication of persistent EV in the CNS with potentially dangerous neurological complications (Schilthuizen et al., 2010; Servais et al., 2010)."
Dr. Byron Hyde on catching Polio in School
I believe "Myalgic Encephalomyelitis (M.E.)", "Post-Infectious Disease Syndrome (Chronic Fatigue Syndrome)", "Lyme Disease" and "Post-Concussion Syndrome (Traumatic Brain Injury)" should be classified under a new category of "Neuro-Endocrine, Immunological, Nutritional and Metabolic" conditions because the current best evidence suggests that's where they should be categorized.
ENDOCRINE - Hypothalamic-Pituitary Dysfunction - Hormone Deficiencies
NEUROLOGICAL - Orthostatic Intolerance - Autonomic Nervous System Disorder (Dysautonomia) - Postural Tachycardia Syndrome (PoTS), Orthostatic Hypotension (OH) or Neurally Mediated Hypotension (NMH)
IMMUNOLOGICAL - Immune Dysfunction (Higher Th2 than Th1) - Inflammation, Allergy and Mast Cell Activation Syndrome (MCAS)
NUTRITIONAL - Mitochondrial Dysfunction (Mitochondrial Encephalopathy and Myopathy) - Nutritional Deficiencies
METABOLIC - Metabolic Syndrome & Lactic Acidosis
Complete your signature
0 have signed. Let’s get to 1,000!