Reclusive by nature, Mephesto spends much of his time alone with his sons at the South Park Genetic Engineering Ranch, working on his experiments and looking after his various animal hybrids, but he is still always happy to help out children interested in the wonders of science, or assist others in need of his unique services. On the odd occasions, he ventures into town for town hall meetings, a quick drink, or a dire warning about an experiment actively endangering the townspeople. Whenever the people in town need help dealing with the supernatural, the extraordinary or the insane, Dr. Mephesto is there with a convoluted, multi-assed solution to their problems.

PERSONALITY AND TRAITS  Despite his pursuit of mad science despite logic to the contrary, Mephesto is not incapable of recognizing his mistakes and feels a great deal of remorse for both the harm his creations cause others as well as the deaths of his creations, even when he has had to perform the act himself for others' safety. He refers to his turkeys as a part of himself, and is saddened to see multi-assed cats taken down by the New Kid, and after these events of destruction often experiences self-doubt about his role as a genetic engineer and the ethics of whether or not he should perhaps be playing God after all. He also exhibits remorse for the conspiracy surrounding Eric Cartman's paternity, bowing his head as he confirms his father's identity.