A crazy finish, that ended in controversy. 
Miami's lateral kickoff return with 6 seconds was a beauty, but it was loaded with blown calls which gave the game to Miami when it shouldn't have. 

With a block in the back flag which was wrongfully overturned, when you can't review a B.I.T.B penalty, along with a missed block in the back, and the player's knee being down when he still had a possession, this sequence was a train wreck. 
On top of those, minor penalties such as the coach running onto the field when the play was still occurring, and a player taking off his helmet happened, but neither impacted the game like the missed calls. 

This play cost Duke the game, but it may have put them out of the ACC Championship later this December as well. It's a play that needs to be appealed and fixed by the ACC, awarding Duke with the win.