Being healthy is the most important aspect of the human livelihood. Global risk and fears of various diseases such as, tuberculosis, HIV/AIDS, polio, malaria and now Covid-19 etc. are still in existence that cause serious population health issues. Some of these diseases are here to stay for a long period and health agencies as well as people have to adopt to measure to use to live within it for the sake of our well-being. Within the Sub-Saharan Africa and Southern Asia, some of these diseases like polio, malaria, tuberculosis and disease like pneumonia, diarrhea, measles respectively accounts to most deaths especially child deaths; 4 out of every 5 children who die before age five are from these regions. However, significant improvement has been made by various agencies like WHO, UN, UNICEF etc. to reduce these diseases and guarantee human’s well-being but more efforts are needed from both nation’s governance bodies and citizens in order to respond to their global existence. Therefore, people and communities must work together in a participatory and inclusive way across different sectors and levels to educate, develop and implement successful preventive measures that will sustain a conducive health and well-being of the world population.