EFV 400mg treatment option for PLHIV in Malaysia

EFV 400mg treatment option for PLHIV in Malaysia

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Gyfer Lim started this petition to Malaysian AIDS Council (Malaysian AIDS Council) and

The objective of this petition is to show patients who receive 400mg Efavirenz combination therapy had comparable viral suppression to 600mg once daily treatment. (ENCORE-1 findings).

Efficacy and safety of efavirenz 400 mg daily versus 600 mg daily are well documented since 2015. 

Fewer efavirenz-related adverse events were reported with the 400 mg efavirenz dose than with the 600 mg dose. 600mg Efavirenz (EFV)-based once daily combination therapy is one of the first-line treatment of HIV-infected patients, but 400mg Efavirenz option is not given as option to treat HIV-infected patients in Malaysia. 

Findings suggest that a reduced dose of 400 mg efavirenz is non-inferior to the standard dose of 600 mg, when combined with tenofovir and emtricitabine during 48 & 96 weeks in ART-naive adults with HIV-1 infection. Adverse events related to the study drug were more frequent with 600 mg efavirenz than with 400 mg. Lower dose efavirenz should be recommended as part of routine care.


Reference
1. http://i-base.info/htb/33430
2. https://www.ncbi.nlm.nih.gov/pubmed/24522178
3. https://www.ncbi.nlm.nih.gov/pubmed/25877963
4. http://regist2.virology-education.com/2014/15HIVHEP_PK/2_Dickinson.pdf
5. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)62187-X/fulltext
6. https://www.researchgate.net/publication/268234234_Efavirenz_400_mg_daily_remains_non-inferior_to_600_mg_96_week_data_from_the_double-blind_placebo-controlled_ENCORE1_study

0 have signed. Let’s get to 100!
At 100 signatures, this petition is more likely to be featured in recommendations!