PFIZER, INC.: Need Pfizer to make drug CDK available for 6 yr. old boy's brain tumor.
  • Petitioned PFIZER, INC.

This petition was delivered to:

PFIZER, INC.

PFIZER, INC.: Need Pfizer to make drug CDK available for 6 yr. old boy's brain tumor.

    1. Brian Gilbertson
    2. Petition by

      Brian Gilbertson

      Lino Lakes, MN

  1.  
  2.   
January 2013

Victory

Brian Gilbertson: Pfizer has approved the one time use of CDK for Gavin's brain tumor. This experimental drug has only been used on adults thus far with favorable results on the kind of tumor that he has. His doctors thought that this is likely his only hope. Pfizer was aware of our Change.org petition and perhaps that helped us keep their attention for our case.

Gavin is a 6 year old from Ramsey, MN. He was a healthy, active boy until April of 2012. Gavin's eyes seemed to be watery and he had trouble looking up for a couple days. On Saturday April 7th, at his sisters birthday party, his family's worst nightmare became their reality. After a family doctor looked at Gavin, she said he needed to be brought to Children's hospital. Within hours, they were told that Gavin had a brain tumor. Gavin has spent the past 9 months having chemo, and multiple surgeries to gradually reduce the tumor. Gavin is scheduled to have his 5th surgery within this next week.
His doctors are treating him with an Interferon treatment to reduce the growth of the tumor so that they can remove it fully. The doctor stated that unless something changed he does not think he could entirely remove all of the tumor. One of the doctors is trying really hard to get the drug CDK as a back-up if the Interferon doesn't work. CDK has been used in Gavin's type of tumor in clinical trials with adults but not yet in children. If the tumor could be shrunk, it could become completely resectable.
The family has been confronted about the severe risks associated with continued surgeries and told that the alternative would be to discontinue surgeries. Gavin would deteriorate, lose motor function, and pass away in a few months.
Gavin's family is devastated but absolutely won't give up. Pfizer wouldn't give the drug for his treatment last year. They're hoping that Pfizer will reconsider their making CDK available for Gavin as it appears to be their only hope at this point.

Gavin needs a Miracle!

Please visit Gavin's Army on Facebook at https://www.facebook.com/gavinsarmy.pierson#!/pages/Please-SAVE-GAVIN/399839830102268

To:
PFIZER, INC.
Need Pfizer to make drug CDK available for 7 yr. old boy's brain tumor.

Sincerely,
[Your name]

Recent signatures

    News

    1. Local CBS Station does update story on Gavin 4-13-13

      Brian Gilbertson
      Petition Organizer

      Gavin is doing amazing since receiving his new drug. Thanks to everyone that signed the petition to get this drug! This may have saved his life. http://minnesota.cbslocal.com/2013/04/13/boy-battling-bully-brain-tumor-lives-marine-biology-dreams/

      Boy Battling 'Bully' Brain Tumor Lives Marine Biology Dreams

      MINNEAPOLIS (WCCO) - A Twin Cities boy who's dealing with a life-threatening brain tumor is getting the chance to live his dream of becoming a marine biologist. Gavin Pierson got rare, behind-the-scenes access at SEA LIFE at the Mall of America.

    2. The drug is working!!!

      Brian Gilbertson
      Petition Organizer

      "The medicine is working!!! The tumor is stable- no growth. We are so happy to say this- I can't even describe the feeling!" -Gavin's Mom 2/28/13

    3. Pfizer has approved the drug for Gavin!

      Brian Gilbertson
      Petition Organizer

      Gavin's mom says, "Steve just called me after talking with Dr. Bendel. She told him that Pfizers pediatric board met today and APPROVED the drug for Gavin!!!!!!!!!!!!!!!!!!! I am so happy right now I'm crying - the only kind of tears Gavin wants to see from me. God is great and continues to give us a way when it seems there isn't one. CHOOSE HOPE!!"

      The family could certainly use your support during these times. As his treatment continues there's still a long road ahead full of therapy, days of missed work, etc. http://www.giveforward.com/supportgavin?utm_source=facebook&utm_medium=fb_wall&utm_campaign=vanity_page&og_action=hug&fb_ref=640237

      Help Support Support Gavin

      Please help raise money to help Gavin and his family while he continues to undergo treatment for his brain tumor.

    4. Good news?

      Brian Gilbertson
      Petition Organizer

      Gavin's tumor came back positive for the RB protein. Pfizer has requested Gavin's lab work to help with dosing. They have not officially said they are sending the drug but it's great to know that they're working on his case.
      A fund has been set-up to help with medical expenses and household expenses so Gavin's parents can focus on his care during this incredibly difficult time in their lives. http://www.giveforward.com/supportgavin?utm_source=facebook&utm_medium=graph&utm_campaign=vanity_page

      Help Support Support Gavin

      Please help raise money to help Gavin and his family while he continues to undergo treatment for his brain tumor.

    5. Gavin's Story aired last night on Twin Citie's Kare 11

      Brian Gilbertson
      Petition Organizer

      Thanks to Kare 11 for airing Gavin's Story. Please continue to spread the word of this petition.
      On their CaringBridge website his mom says, "Hopefully by Monday or Tuesday we will get the results from the University of Penn about Gavin's tumor expressing the RB protein. This is what the CDK inhibitor would attack. Every mature teratoma I've read about has expressed high levels of this so it is looking more and more promising. "

      http://www.kare11.com/video/2106106917001/1/Family-pleads-for-help-from-drug-company?fb_action_ids=10152457284950074&fb_action_types=og.recommends&fb_source=other_multiline&action_object_map=%7B%2210152457284950074%22%3A151602934990923%7D&action_type_map=%7B%2210152457284950074%22%3A%22og.recommends%22%7D&action_ref_map=[]

      Family pleads for help from drug company

      A Ramsey family is asking a major pharmaceutical company to allow their son to take an experimental drug that could save his life

    6. Reached 3,000 signatures
    7. The latest from Gavin's mom:

      Brian Gilbertson
      Petition Organizer

      "Dr. S has filled out a lot of paperwork applying for "single use" of an investigational drug. Children's hospital has a committee that will be meeting next Wednesday to approve going forward and Dr. S said that they should approve it its more of a formality. In the meantime, the University of Pennsylvania is testing Gavin's tumor for RB protein. This should be done by Monday and they will send Children's the results. Once we have those we will send the results along with approval from children's and paperwork to Pfizer who will make their decision. Then we send more paperwork with their approval to the FDA who assigns a case number and then allows Pfizer to release the drug."

      Please continue to spread the word of our petition.

    8. Reached 2,500 signatures
    9. Please continue spreading the word of our petition.

      Brian Gilbertson
      Petition Organizer

      Gavin visited Children's Hospital today with his family in preparation for his surgery tomorrow. He was excited to see Travis, his favorite nurse, today. Afterwards they were off to the the zoo where Gavin saw his favorite, a komodo dragon.

      The family has asked for your prayers and continuing to spread the word of this petition. You can also spread the word with a "like" of his facebook page at: https://www.facebook.com/gavinsarmy.pierson?

      https://dl.dropbox.com/u/56027416/gavinwithsiblings.jpg
      https://dl.dropbox.com/u/56027416/cure4gavin.jpg
      https://dl.dropbox.com/u/56027416/gavin%20dad.jpg
      fref=ts#!/pages/Please-SAVE-GAVIN/399839830102268

    10. The word is spreading, Pfizer is "working on it" :)

      Brian Gilbertson
      Petition Organizer

      Here's the latest from Nicole, Gavin's mother.

      "Dr. S talked to Pfizer. They are "working on it". This means they are figuring out dosing, and they will be examining a tumor specimen of Joe Bully to make sure it is positive for RB (this is what CDK can arrest - stop). Here is an explanation of what that is and why it is important that Gavs tumor has it:
      Although embryonal carcinomas express little or no retinoblastoma protein (pRB),3 mature teratomas express high levels of pRB. Normally, cyclin-dependent kinase 4/6 (CDK4/6) stimulates cell growth by phosphorylating pRB. The development of selective CDK inhibitors,4 including PD0332991 (Pfizer), which selectively inhibits CDK4/6, suggests a new treatment for growing teratoma syndrome."

      "Thank you all so much for signing the petition, for all of your kind words and prayers. Gavin is having surgery Monday and this always has risks. Please keep praying, God is listening." -Nicole, Gavin's Mom

    11. Reached 1,500 signatures
    12. Update on Gavin's Care

      Brian Gilbertson
      Petition Organizer

      This is part of what Gavin's mom posted on Gavin's CaringBridge website today:

      "Dr. Schultz finally got Pfizer to discuss Gavin at their compassionate use meeting tomorrow morning. She has informed Pfizer of this petition and of the thousands of people ready to fight with us for it. I have researched this drug so much, I could almost explain the science behind it - and even though it is scary to have my child be the first child to use it, it shows promising results in adults and it is a better option than doing nothing. I have seen a few comments here and there on Gavs facebook page from people that have questioned why we would give our child an experimental drug. My aunt who is a doctor and did research for NIH, as well as Gavs oncologist have extensively researched this and feel it would work better than Interferon."

      Please continue to help by spreading the word of our petition. Any help getting this to the media would be so much appreciated.

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    13. Reached 1,000 signatures

    Supporters

    Reasons for signing

    • Channing Stark BLAINE, MN
      • over 1 year ago

      KIds should not have to fight cancer!

      REPORT THIS COMMENT:
    • Kayla Darveaux HAM LAKE, MN
      • over 1 year ago

      Stay strong Gavin

      REPORT THIS COMMENT:
    • Elizabeth Ortloff DULUTH, MN
      • over 1 year ago

      Kids need every chance they can get to be healthy

      REPORT THIS COMMENT:
    • Ann Faulds OSSEO, MN
      • over 1 year ago

      The boys parents should be able to make this decision for their son, not the drug company.

      REPORT THIS COMMENT:
    • Angela Saverice-Rohan PASADENA, CA
      • over 1 year ago

      Please help Gavin. I understand the onerous drug trial process and legal risks that a drug manufacturer fears. But, in the end, drugs are to save people. We can't lose sight of that. Pfizer, please give this child what may be his only chance.

      REPORT THIS COMMENT:

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