Here's the latest from Nicole, Gavin's mother.
"Dr. S talked to Pfizer. They are "working on it". This means they are figuring out dosing, and they will be examining a tumor specimen of Joe Bully to make sure it is positive for RB (this is what CDK can arrest - stop). Here is an explanation of what that is and why it is important that Gavs tumor has it:
Although embryonal carcinomas express little or no retinoblastoma protein (pRB),3 mature teratomas express high levels of pRB. Normally, cyclin-dependent kinase 4/6 (CDK4/6) stimulates cell growth by phosphorylating pRB. The development of selective CDK inhibitors,4 including PD0332991 (Pfizer), which selectively inhibits CDK4/6, suggests a new treatment for growing teratoma syndrome."
"Thank you all so much for signing the petition, for all of your kind words and prayers. Gavin is having surgery Monday and this always has risks. Please keep praying, God is listening." -Nicole, Gavin's Mom